Global NGS Sample Preparation Market Size By Product (Reagents & Consumables, Workstations), By Workflow (DNA Fragmentation & Library Preparation, Target Enrichment), By Sample Type (DNA, RNA), By Application (Diagnostics, Drug Discovery), By End-User (Academic Institute & Clinical Research Institute, Hospital & Clinics), By Geographic Scope And Forecast

NGS Sample Preparation Market Size And Forecast

NGS Sample Preparation Market size was valued at USD 1.68 Billion in 2021 and is projected to reach USD 5.2 Billion by 2030 growing at a CAGR of 13.4% from 2023 to 2030.

The development of low-cost sequencing technologies and the growing acceptance of NGS in diagnostics are two key drivers driving the growth of the global market in terms of revenue. The rising frequency of genetic abnormalities in infectious and chronic diseases, as well as the use of NGS in cancer diagnosis and treatment, are a few key factors propelling the growth of the NGS Sample Preparation Market. The Global NGS Sample Preparation Market report provides a holistic evaluation of the market. The report offers a comprehensive analysis of key segments, trends, drivers, restraints, competitive landscape, and factors that are playing a substantial role in the market.

Global NGS Sample Preparation Market Definition

Next-generation sequencing (NGS) sample preparation is a crucial step in genomics research and involves the transformation of biological samples into a format suitable for sequencing on NGS platforms. The NGS Sample Preparation Market offers a range of products and services to facilitate this process, ensuring accurate and high-quality sequencing data. The goal of NGS sample preparation is to generate high-quality sequencing data by properly preparing the biological sample for sequencing.

This involves breaking down the DNA or RNA into smaller fragments, adding adapters or barcodes to the fragments for identification, amplifying the fragments if necessary, and performing quality control checks to ensure the accuracy and reliability of the sequencing results. NGS sample preparation may also involve target enrichment techniques, which selectively capture specific genomic regions of interest for sequencing, allowing researchers to focus on particular genes or regions in the genome.

The NGS Sample Preparation Market offers a variety of products and services to support each of these steps. Numerous companies provide kits, reagents, and instruments specifically designed for DNA fragmentation, library preparation, target enrichment, and quality control in NGS workflows. These products aim to streamline the sample preparation process, enhance sequencing efficiency, and improve the overall quality of sequencing data.

The NGS Sample Preparation Market can be segmented based on product, workflow, sample type, application, and end user. The product segment includes reagents & consumables, workstations, and services. Reagents & consumables consist of kits and materials needed for sample preparation, while workstations involve instruments and automated systems. Services encompass specialized offerings like sequencing and data analysis.

The workflow segment comprises DNA fragmentation & library preparation, target enrichment, and quality control processes. The sample type focuses on DNA and RNA preparations. Applications include diagnostics, drug discovery, agricultural & animal research, and others. The end users are academic institutes & research institutes, hospitals & clinics, pharma & biotech companies, and others.

Global NGS Sample Preparation Market Overview

The increased efficiency of genotyping and preparation methods is one of the main factors driving the market for NGS sample preparation. Human whole genome sequencing has experienced exponential growth in recent years, setting new benchmarks for genotyping, particularly in bacterial infection outbreak investigations. NGS sample preparation has emerged as a leading technology for genotyping in such scenarios. Illumina devices are widely used for NGS sample preparation, but protocols from other major players like ThermoFisher and PerkinElmer are also available.

The efficiency of genotyping and preparation protocols in NGS sample preparation plays a vital role in accelerating research, outbreak investigations, and various applications in genomics. The continuous advancements in protocols and technologies contribute to the growth of the NGS Sample Preparation Market by providing researchers with improved tools and methodologies for efficient and high-quality sample preparation. The availability of alternative technologies is one of the major barriers to the market for NGS sample preparation.

While NGS has revolutionized genomic research and diagnostics, other techniques such as Sanger sequencing, antigen tests, polymerase chain reaction (PCR), and serological tests continue to be used for disease diagnosis. Sanger sequencing, which has been dominant in genomic research for the past two decades, has achieved significant milestones in genomics. Antigen tests are commonly employed to detect specific viral or bacterial antigens, providing rapid results. PCR is widely utilized for DNA amplification and detection of specific sequences.

Serological tests, on the other hand, detect antibodies in the blood and are used to determine the viral presence or antibody response to certain infections. These alternative technologies offer specific advantages, established protocols, and familiarity, which can limit the adoption and market growth of NGS sample preparation in certain applications and regions. However, the NGS Sample Preparation Market arises from the increasing collaborations and partnerships among key players. Major companies like Illumina, Thermo Fisher Scientific, and PerkinElmer are actively engaging in collaborations with research laboratories, academic institutes, hospitals, clinics, and other pharmaceutical and biotechnology companies.

These partnerships facilitate the introduction of new technologies, products, and research projects into the market. The collaborative efforts aim to address the evolving needs and challenges in NGS sample preparation, driving advancements and innovation. Additionally, these collaborations expand the reach and customer base for NGS sample preparation products and services. They enhance market penetration and offer avenues for joint research projects, resulting in the creation of unique value propositions and competitive advantages.

Global NGS Sample Preparation Market Segmentation Analysis

The Global NGS Sample Preparation Market is Segmented on the basis of Product, Workflow, Sample Type, Application, End-User, And Geography.

NGS Sample Preparation Market, By Product

• Reagents & Consumables
• Workstations
• Services

Based on Product, the market is segmented into Reagents & Consumables, Workstations, and Services. The workstation/instruments segment dominated the product and services segment of the NGS Sample Preparation Market. There is a growing demand for automation in NGS sample preparation workflows to enhance efficiency, reduce manual labor, and ensure consistency in the results. Workstations and instruments designed specifically for NGS sample preparation play a crucial role in automating various steps, such as DNA/RNA fragmentation, library preparation, and target enrichment. This automation enables higher throughput, minimizes human errors, and increases overall productivity.

NGS Sample Preparation Market, By Workflow

• DNA Fragmentation & Library Preparation
• Target Enrichment
• QC

Based on Workflow, the market is segmented into DNA Fragmentation & Library Preparation, Target Enrichment, and QC. The library preparation segment dominated the workflow segment with the highest market share. The library preparation approach combines both manual and automated methods for the preparation of NGS libraries. This hybrid approach offers advantages in terms of flexibility and control over the library preparation process. Researchers can perform critical steps manually while leveraging automation for specific tasks, such as the ligation of barcoded molecular adaptors, end repair, and purification reactions. This combination of manual and automated processes contributes to the efficiency and accuracy of library preparation, driving the growth of the library preparation segment.

NGS Sample Preparation Market, By Sample Type

• DNA
• RNA

Based on Sample Type, the market is segmented into DNA and RNA. The DNA segment accounted for the largest share of the sample type segment of the NGS Sample Preparation Market. DNA-based analysis plays a crucial role in understanding the genetic basis of cancer. With the increasing prevalence of cancer cases worldwide, there is a growing demand for DNA sample preparation in NGS workflows. DNA sequencing enables the identification of genetic mutations, variations, and biomarkers associated with cancer, facilitating personalized treatment approaches and precision medicine.

NGS Sample Preparation Market, By Application

• Diagnostics
• Drug Discovery
• Agricultural & Animal Research
• Others

Based on Application, the market is segmented into Diagnostics, Drug Discovery, Agricultural & Animal research, and Others. The diagnostics segment has generated the highest revenue in the application segment of the NGS Sample Preparation Market. NGS-based diagnostics have proven to be highly effective in the early and accurate detection of infectious diseases. NGS sample preparation enables the identification and characterization of pathogens, including viruses, bacteria, and fungi, facilitating rapid and precise diagnosis for timely treatment and control of infectious diseases.

NGS Sample Preparation Market, By End-User

• Academic Institute & Clinical Research Institute
• Hospital & Clinics
• Pharma & Biotech companies
• Others

Based on End-User, the market is segmented into Academic Institute & Clinical Research Institute, Hospital & Clinics, Pharma & Biotech companies, and Others. The clinical research segment dominated the market with a significant market share. The massive adoption of NGS in cancer research has played a major role in driving the growth of the clinical research segment. NGS technology has been instrumental in the discovery of new cancer-related genes, the study of tumor heterogeneity, and the identification of genetic changes that contribute to tumor genesis. Additionally, the increase in funding from government agencies has contributed to the penetration of NGS technology in clinical research laboratories. Government initiatives and grants aimed at advancing genomics research have provided resources and support for the adoption of NGS technology in clinical settings. This funding has fueled the growth of the clinical research segment and facilitated the integration of NGS sample preparation in various clinical studies and trials.

NGS Sample Preparation Market, By Geography

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa

Based on Regional Analysis, the Global NGS Sample Preparation Market is classified into North America, Europe, Asia Pacific, Latin America, and Middle East and Africa. North America has been a significant market for NGS sample preparation, and its dominance in the market is expected to continue throughout the forecast period. Government and private bodies in North America have been actively promoting the adoption of NGS technologies through supportive initiatives and policies. These efforts have created a conducive environment for the growth of the NGS Sample Preparation Market. Increased awareness and understanding of the benefits of NGS services and advancements in genomic medicine have led to a higher adoption rate of NGS sample preparation in North America. Researchers, clinicians, and pharmaceutical companies are increasingly incorporating NGS technologies into their workflows.

Key Players

The “Global NGS Sample Preparation Market” study report will provide a valuable insight with an emphasis on the global market. The major players in the market are ILLUMINA, INC., Thermo Fisher Scientific Inc., PerkinElmer Inc., F. Hoffmann-La Roche Ltd, AGILENT TECHNOLOGIES, INC., Danaher, Becton, Dickinson and Company, Merck KGAA, QIAGEN, Bio-Rad Laboratories, PROMEGA CORPORATION, TECAN TRADING AG, Oxford Nanopore Technologies PLC, EUROFINS SCIENTIFIC, SWIFT BIOSCIENCES INC., SYSMEX CORPORATION, and Takara Bio Inc. 

Our market analysis also entails a section solely dedicated for such major players wherein our analysts provide an insight to the financial statements of all the major players, along with its product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share and market ranking analysis of the above-mentioned players globally.

Key Developments

• Resolution Bioscience, a pioneer in the development and commercialization of NGS-based precision cancer treatments, was acquired by Agilent in 2021. Agilent’s NGS-based cancer detection capabilities were complemented and improved by Resolution Bioscience, which also gave Agilent access to cutting-edge technology to better meet the demands of the rapidly expanding precision medicine market.
• Roche said in 2020 that it has partnered with Illumina for a non-exclusive 15-year period in order to expand the use of distributable next-generation sequencing (NGS)-based tests in cancer.
• Thermo Fisher Scientific said in 2021 that it will purchase PPD, a provider of clinical research services.

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• Qualitative and quantitative analysis of the market based on segmentation involving both economic as well as non-economic factors• Provision of market value (USD Billion) data for each segment and sub-segment• Indicates the region and segment that is expected to witness the fastest growth as well as to dominate the market• Analysis by geography highlighting the consumption of the product/service in the region as well as indicating the factors that are affecting the market within each region• Competitive landscape which incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions, and acquisitions in the past five years of companies profiled• Extensive company profiles comprising of company overview, company insights, product bench