Global Protein A Resin Market Size By Product (Agarose-Based Protein A, Glass/Silica-Based Protein A), By Type (Recombinant Protein A, Natural Protein A), By Application (Antibodies Purification, Immunoprecipitation), By Geographic Scope And Forecast

Protein A Resin Market Size And Forecast

Protein A Resin Market size was valued at USD 1.87 Billion in 2024 and is projected to reach USD 4.2 Billion by 2031, growing at a CAGR of 10.60% from 2024 to 2031.

The Protein A Resin Market has witnessed rising utilization because of expansion monoclonal antibody production on account of the pandemic situation worldwide. The rise in the market can mainly be attributed to elements such as demand for pre-packed disposable columns, increasing demand for therapeutic antibodies, and increasing pharmaceutical R&D spending. Furthermore, biopharmaceutical industries are extensively using protein-engineered products in their research activities to develop a wide range of protein-based drugs.

Global Protein A Resin Market Definition

Protein A Resin is an affinity chromatography medium designed for easy, one-step purification of classes, subclasses, and fragments of immunoglobulin are from biological fluids and from cell culture media. Protein A Resin can also be used for immunoprecipitation of proteins, protein complexes, or antigens. The recombinant protein A ligand is coupled to agarose. The coupling is optimized to give a high binding capacity for immunoglobulin. The static binding capacity of Protein A Resin is higher than 20 mg human IgG/ml settled resin.

The dynamic binding capacity will vary depending on certain factors such as flow rate, target antibody, etc. Protein A is a bacterial cell wall protein outlying from Staphylococcus aureus that combine to mammalian mainly through Fc regions. Native protein A has five IgG binding domains and many other domains with unknown functions. Recombinant protein A contains five high-affinity IgG binding domains with other non-essential domains removed to reduce nonspecific binding. It is composed of five immunoglobulin-binding domains, each of which is able to bind proteins from many mammalian species, most notably Immunoglobulin G (IgG) through the heavy chain within the Fc region.

Protein A resins are the most frequently used affinity resins in biomanufacturing. Growing investment in synthetic biology and increasing focus on drug development by biotechnology and pharmaceutical companies will propel the industry’s growth. The biopharmaceutical industry is broadly using protein-engineered products in their research activities to develop a broad range of protein-based drugs. Because of the high selectivity and affinity of protein A resins, 99 percent purity can be gained in the most generic form.

Global Protein A Resin Market Overview

The rise in alternate methods for the purification of monoclonal antibodies is expected to hinder the growth of the global Protein A Resin Market. Affinity chromatography, which utilizes protein A resin, is a conventional method for the purification of monoclonal antibodies. Though, the cost and availability of protein A resin are very high to execute the purification procedure. To decrease manufacturing costs, several companies prefer alternative methods such as membrane chromatography, aqueous two-phase extractions and, mixed chromatography for purification of monoclonal antibodies on large scales. Moreover, high costs associated with protein A resin is also expected to hinder the growth of the market.

The rising popularity of cancer is expected to expand the manufacturing of monoclonal antibodies for use in therapeutic areas. The potential approach of monoclonal antibodies in the treatment of several cancers types has been broadly accepted. Each cancer type needs unique treatment.Thus, it will eventually give opportunities for market players by driving sales of protein A resin over the upcoming years. Further rising use of chromatography in drug discovery and R & D industry these are extensively using protein engineered products in their research activities to develop a wide range of protein-based drugs. Initiatives of researchers to develop a novel machine for generating synthetic proteins is an advantage for the growth of the market.

The biologics segment in the life sciences industry has secured major acceptance by biotechnology and other research institutes for their areas of research, as it has shown favorable results as well as low side effects in the treatment of different diseases, such as cancer, autoimmune diseases, and several genetic conditions. Biologic therapies, being more target-mediated than non-biologic treatments, are also used as a first-line treatment in certain cancer cases. Biologics is the fastest-growing segment in the healthcare industry, with monoclonal antibodies being the key product.

Global Protein A Resin Market Segmentation Analysis

The Global Protein A Resin Market is segmented on the basis of Product, Type, Application, And Geography.

Protein A Resin Market, By Product

• Agarose-Based Protein A• Glass/Silica-Based Protein A• Organic Polymer-Based Protein A

Based on Product, The market is bifurcated into Agarose-Based, Glass/Silica-Based and Organic Polymer-Based Protein A on the basis of Type. The agarose-based protein A segment is holding the largest share of the Protein A Resin Market. Owing to its big gelling strength at low concentrations, anti-convection medium for, suitable pH range, gel electrophoresis and superior mechanical strength, this segment expected a significant growth in the upcoming years.

Protein A Resin Market, By Type

• Recombinant Protein A• Natural Protein A

Based on Type, The market is bifurcated into Recombinant and Natural Protein A on the basis of Type. In today’s market Recombinant Protein, A holds the big share. Recombinant protein A is majorly used to upgrade solubility and to normalize the sensitivity of alkaline solutions. With the rising pharmaceuticals industry and expanding technological advancements in new drug development, the segment will grow at a significant rate. Natural protein A is derived from a bacterial cell of the staphylococcus aureus species and mainly used in the purification of monoclonal antibodies.

Protein A Resin Market, By Application

• Antibodies Purification• Immunoprecipitation

Based on Application, The market is bifurcated into Antibodies Purification and Immunoprecipitation on the basis of Application. The antibodies purification segment holds the largest share. The significance of antibody purification is constantly increasing owing to the achievement of fine grade purity of antibodies. Moreover, broad use of chromatography, technological advancements, and practical uses of antibody purification will increase its preference over immunoprecipitation.

Protein A Resin Market, By Geography

• North America• Europe• Asia Pacific• Rest of the world

On the basis of Regional Analysis, The Global Protein A Resin Market is classified into North America, Europe, Asia Pacific, and Rest of the world. North America expected a significant growth in the Protein A Resin Market owing to the rising demand for pharmaceuticals and biopharmaceuticals and the presence of major market players constantly investing in research and development activities in North America expected to fuel the Protein A Resin Market.

Key Players

The “Global Protein A Resin Market” study report will provide valuable insight with an emphasis on the global market. The major players in the market are Purolite Corporation, Novasep Holding SAS, Agilent Technologies, GenScript Biotech Corporation, PerkinElmer, GE Healthcare, Merck Millipore, Repligen Corporation, Thermo Fisher Scientific, Tosoh Bioscience and among others.

Our market analysis also entails a section solely dedicated to such major players wherein our analysts provide an insight to the financial statements of all the major players, along with its product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share, and market ranking analysis of the above-mentioned players globally.

Key Developments

• In 2017, Purolite Life Sciences collaborated with ChromaTan Corporation (US), which provides chromatography solutions. The development rising the manufacturing of protein A resins by up to 15 times.

• In 2018, Merck Millipore (Germany) starting a new production and distribution center in India for its Life Science business.

• In 2017, Repligen Corporation merged with Spectrum Inc. a leader in membrane separation technologies for the pharmaceutical, bioprocess, diagnostic, and research industries.

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