Global Gamma-Aminobutyric Acid (GABA) Market Size By Type (Chemical Synthesis, Biological Fermentation), By Application (Food And Beverage, Pharmaceuticals And Health, Animal Feeds), By Geographic Scope And Forecast

Gamma-Aminobutyric Acid (GABA) Market Size And Forecast

Gamma-Aminobutyric Acid (GABA) Market size was valued at USD 81.16 Million in 2022 and is projected to reach USD 122.36 Million by 2030, growing at a CAGR of 5.32% from 2023 to 2030.   

The driving factor of the Global Gamma-Aminobutyric Acid (GABA) Market is the increasing number of neurological disorders among different individuals across the globe. Additionally, the prevalence of Alzheimer’s illnesses has increased due to the expanding population of people between the ages of 60 and 65, which has had an impact on the market’s expansion. The probability of developing this disorder doubles every five years after the age of 65 owing to the increase in the demand for the market.

Furthermore, poor food and beverage consumption might worsen mental diseases due to changes in lifestyle and health problems. It is projected that this aspect will have an impact on Global GABA Market demand. Additionally, it is anticipated that a rise in investments made by public and commercial entities throughout developing countries for the treatment of neurological illnesses will fuel a significant increase in market demand.

The Global Gamma-Aminobutyric Acid (GABA) Market report provides a holistic evaluation of the market. The report offers a comprehensive analysis of key segments, trends, drivers, restraints, competitive landscape, and factors that are playing a substantial role in the market.

Global Gamma-Aminobutyric Acid (GABA) Market Definition

GABA (Gamma-aminobutyric acid) is a four-carbon non-protein amino acid that is widely distributed in plants, animals, and microorganisms. Gamma-aminobutyric acid (GABA) is widely distributed in nature and considered a potent bioactive compound with numerous important physiological functions, such as anti-hypertensive and antidepressant activities. There has been an ever-growing demand for GABA production in recent years. It is produced from glutamic acid by glutamate decarboxylase (GAD) and is widely present in microorganisms, plants, and animals.

In the brain, gamma-aminobutyric acid (GABA) functions as a neurotransmitter or chemical messenger. It works by obstructing particular signals in the central nervous system (brain and spinal cord), and it slows down the brain. GABA is well known for its relaxing effects. It is believed to play a significant part in regulating nerve cell hyperactivity linked to anxiety, stress, and terror.

GABA is found in some foods as well as in the brain. People use GABA for many different conditions, including stress, anxiety, depression, and high blood pressure. There are also a few diseases that are caused due fluctuating GABA levels. Autism and Parkinson’s disease are just a few of the diseases and disorders that have been related to fluctuating GABA levels. Also many drugs work by binding to GABA receptors. And GABA supplements are used to reduce stress and anxiety as well as fight sleeplessness.

A wide range of traditional foods produced by microbial fermentation contains Gamma-aminobutyric acid. Also, GABA is safe and eco-friendly, and hence it also has the possibility of providing new health-benefited by products enriched with GABA. Major GABA-producing microorganisms are lactic acid bacteria. Lactic acid bacteria (LAB) are one of the most important GABA producers because of their food-grade nature and potential to produce GABA-rich functional foods directly.

At present, food containing GABA cannot meet people’s needs because of the low content of GABA. Microorganisms are an important source of GABA. Up to now, it has been confirmed that many types of microorganisms can synthesize GABA, including yeast, fungi, and bacteria. Microorganisms grow faster than plants, do not need much space for cultivation, and are eco-friendly for consumers. Furthermore, it is easy to control the production of microorganisms. This leads to a high production of GABA from microorganisms.

Global Gamma-Aminobutyric Acid (GABA) Market Overview

The key factor that is driving the demand for Gamma-aminobutyric acid (GABA) in the global market is the ability of GABA to provide relaxation to the brain. GABA helps in enhancing the quality of sleep. Since GABA is non-toxic in nature, its usage is usually suggested. Enhancing sleep and improving mood are among the benefits of GABA supplements. Supplements may include GABA alone, but many sleep-focused products combine GABA with other aids. These supplements basically help to slow down brain activity, making it easier to sleep.

According to a study, insufficient sleep and poor quality sleep can be the result of diverse factors, including sleep disorders, medical conditions, and mental health. Sleep issues affect people of all ages, and their impacts touch many parts of people’s lives. This leads to insomnia. And according to a study, one in 3 adults has experienced brief insomnia symptoms, which resolve after a short period. People over the age of 60 are the age group that has the highest reported levels of insomnia. People with insomnia are five times more likely to suffer from depression. These factors are augmenting growth in demand for sleep aids, and which will positively impact the demand for GABA in the global market. The growth of the GABA in the sleep aids market is driven by the benefits of using sleep aids products and the rise in disposable income. Moreover, the surge in the geriatric and obese population has led to an increase in the cases of sleep disorders, which is anticipated to increase the patient population with sleep disorders that contribute toward the growth of the market. The advancement of sleep aid products helps to increase the adoption rate and the untapped market in developing economies, which are expected to offer lucrative opportunities for the growth of the market.

However, High intake of GABA and its supplements is one of the factor that is hindering the market growth. Presently, there are no studies that specifically assess GABA’s safety. However, several clinical trials suggest that GABA is linked to side effects, like for low blood pressure. This will lead consumers to feel faint with low blood pressure. Severe allergic reaction is another serious side effect possible with any medication. The person consuming GABA supplement suffers from a severe allergic reaction to GABA. Symptoms may include breathing difficulties, itchiness, and rash. One of the main risks of any supplement is that it will interfere with the prescription or over-the-counter meds. For example, it might lead to blood pressure concerns in those who take antihypertensive medications. Moreover, pregnant women or those who breastfeed should avoid GABA supplements because it might cause hormonal fluctuations. Also, the low research in long-term side effects of using GABA in various industries is leading to hesitation for its usage in the application sector. This is one of the factors that is leading to lowering of demand for GABA in the global market

Global Gamma-Aminobutyric Acid (GABA) Market Segmentation Analysis

The Global Gamma-Aminobutyric Acid (GABA) Market is segmented on the basis of Type, Application, And Geography.

Gamma-Aminobutyric Acid (GABA) Market, By Type

• Chemical Synthesis
• Biological Fermentation

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Based on Type, the market is divided into Biological Fermentation and chemical Synthesis. Biological Fermentation accounted for the largest market share in 2022. Gamma-aminobutyric acid (GABA) deficiency leads to a neurological disorder. The Global GABA Market is expected to experience tremendous demand as a result of this. A person’s risk of developing a neurological condition can also increase due to the rising stress levels among individuals as a result of their hectic schedules and demanding jobs. The intake of unhealthy food and beverages has also raised the risk of mental health problems. An increase in risk factors, such as diabetes, and frequent alcohol use are expected to lead to the emergence of mental disorders. As a result, various people have developed serious health disorders like anxiety, depression, insomnia, stress and weariness, panic disorder, high blood pressure, and others. This is creating a high demand for GABA for the treatment of various disorders.

Biological fermentation is a method of producing GABA using living microorganisms, such as bacteria or yeast. These microorganisms are selected and often genetically engineered to have the capability of converting precursor molecules into GABA as part of their natural metabolic processes. The fermentation process takes place in bioreactors under controlled conditions, providing the microorganisms with the ideal environment for growth and GABA production.

Specific microorganisms are chosen for their ability to efficiently produce GABA. Genetic engineering techniques may be used to enhance their GABA-producing capabilities. This can involve introducing genes responsible for GABA synthesis into the microorganisms’ genetic material. Microorganisms are cultivated in a fermentation medium that contains nutrients required for their growth and GABA production. This medium can include sources of carbon, nitrogen, minerals, and other essential elements. Microorganisms grow and multiply in the fermentation medium. As they metabolize nutrients, they produce GABA as a metabolic byproduct. Genetic modifications enable them to convert precursor molecules into GABA molecules. The fermentation process is carefully controlled to provide optimal conditions for microorganism growth and GABA production. Factors such as temperature, pH, oxygen supply, and agitation are monitored and adjusted as needed.

Chemical synthesis involves the creation of GABA (gamma-aminobutyric acid) using a series of chemical reactions performed in a controlled laboratory environment. The process starts with precursor molecules, which are compounds that can be transformed into GABA through specific chemical transformations. The goal is to convert these precursors into GABA molecules using various synthetic steps.The choice of precursors is critical in chemical synthesis. Common precursors used for GABA synthesis include glutamic acid or its derivatives. These precursors are modified through chemical reactions to introduce the necessary functional groups for GABA formation. The precursor molecules undergo a series of chemical reactions to introduce or modify specific functional groups. These reactions might involve steps such as decarboxylation (removing a carboxyl group), reduction, or other chemical modifications. These transformations create the GABA structure from the precursor molecules.

Gamma-Aminobutyric Acid (GABA) Market, By Application

• Food and Beverage
• Pharmaceuticals and Health
• Animal Feeds

On the basis of Application, the Global Gamma-Aminobutyric Acid (GABA) Market has been segmented into Pharmaceuticals And Health, Food And Beverage, and Animal Feeds. Pharmaceuticals And Health accounted for the largest market share in 2022. GABA’s role as a neurotransmitter that helps regulate brain activity has led to its investigation as a potential anxiolytic (anxiety-reducing) and relaxant agent. GABA acts as an inhibitory neurotransmitter, which means it can have a calming effect on the nervous system. This property has prompted the use of GABA as an active ingredient in herbal supplements and natural health products that aim to promote relaxation and emotional well-being. Such products are often marketed as alternatives to pharmaceutical drugs and are sought after by individuals seeking a more holistic approach to managing stress and anxiety.

GABA’s calming influence on the nervous system has also led to its exploration as a potential aid for sleep disorders. Some supplements and medications designed to improve sleep quality and duration incorporate GABA as part of their formulations. GABA’s potential to induce relaxation and calmness may contribute to a person’s ability to fall asleep and experience deeper, more restful sleep. However, the effectiveness of GABA for sleep support can vary among individuals, and further research is needed to establish its role in addressing sleep-related issues.

Health drinks that include GABA aim to offer consumers a beverage that promotes a sense of calm and well-being. These drinks typically contain GABA along with other natural ingredients that are associated with relaxation and stress reduction. The concept behind these health drinks is to provide an alternative to traditional energy drinks that often contain stimulants like caffeine. Instead, health drinks with GABA emphasize relaxation and a balanced mood, which can be appealing to those seeking stress relief.

GABA is utilized as a natural food additive to enhance the umami flavor of certain foods and improve overall taste perception. Umami is known as the “fifth taste,” characterized by a savory and satisfying flavor. Adding GABA to foods like soups, sauces, and processed meats can contribute to enhancing the umami taste profile, resulting in a more enjoyable eating experience. By enhancing flavor, GABA contributes to the overall sensory appeal of the food product.

The growth of the GABA in the sleep aids market is driven by the benefits of using sleep aids products and the rise in disposable income. Moreover, the surge in the geriatric and obese population has led to an increase in the cases of sleep disorders, which is anticipated to increase the patient population with sleep disorders that contribute toward the growth of the market. The advancement of sleep aid products helps to increase the adoption rate and the untapped market in developing economies, which are expected to offer lucrative opportunities for the growth of the market.

Gamma-Aminobutyric Acid (GABA) Market, By Geography

• North America
• Europe
• Asia Pacific
• Middle East and Africa
• Latin America

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On the basis of regional analysis, the Global Gamma-Aminobutyric Acid (GABA) Market is classified into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America. North America is expected to hold the largest market share of Gamma-Aminobutyric Acid (GABA) in the forecast period followed by Europe. The US is dominating the North America region followed by Canada and Mexico.

Key Players

The major players in the market are The Richen Nutritional Technology Co., Ltd., ZheJiang YiWan Biolabs Co., Ltd. Inc., Pharma Foods International Co., Ltd., Zhejiang Tianrui Pharmaceutical Co., Ltd., Guangdong Luckerkong Biotech Co., Ltd.., Tocris Bioscience, Tianjin Shijitianlong Biotech Co., Ltd., Taizhou Xinyou Pharmaceutical & Chemical Co., Ltd., Inc., Wuhan Yuancheng Gongchuang Technology Co., Ltd, LLC, Ningxiang Jiayuan Biology Technology Co., Ltd. and others.

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