Global NGS-based RNA-seq Market Size By Product And Service (Sample Preparation Products, Sequencing Platforms And Consumables, Sequencing Services, Data Analysis, Storage And Management), By Technology (Sequencing By Synthesis (SBS), Ion Semiconductor Sequencing, Single-molecule Real-time Sequencin

NGS-based RNA-seq Market Size And Forecast

NGS-based RNA-seq Market size was valued at USD 3.17 Billion in 2023 and is projected to reach USD 12.81 Billion by 2031, growing at a CAGR of 19.05% from 2024 to 2031.

• NGS-based RNA-seq (Next-Generation Sequencing-based RNA sequencing) is a technology that enables a thorough investigation and quantification of a sample’s total RNA content.
• NGS-based RNA-seq converts RNA into a library of cDNA fragments that are then read using high-throughput sequencing methods, which can discover known and novel transcripts, quantify gene expression levels, and uncover alternative splicing events, among other findings.
• NGS-based RNA-seq has many applications, including basic research and clinical diagnostics. In research, it is used to investigate gene expression patterns under various situations, gain a molecular understanding of disease causes, and find prospective treatment targets
• Furthermore, it is useful in the research of infectious illnesses by allowing for pathogen detection and characterization, as well as in agriculture for crop and livestock genetic improvement.

Global NGS-based RNA-seq Market Dynamics

The key market dynamics that are shaping the NGS-based RNA-seq Market include

Key Market Drivers

• Technological Advancements The constant improvement of Next-Generation Sequencing (NGS) technologies has greatly decreased costs while increasing the speed and accuracy of RNA sequencing. This makes NGS-based RNA-seq more accessible and desirable for research and clinical diagnostics, resulting in increased market growth.
• Increased Demand for Personalized Medicine NGS-based RNA-seq has become crucial for understanding the genetic basis of diseases, which is required for the development of personalized therapy. The rising emphasis on individualized treatment approaches drives up the need for RNA-seq in clinical settings.
• Rise in Genetic ResearchThere is an increase in genetic research, particularly in cancer, neurology, and infectious disorders. NGS-based RNA-seq gives detailed insights into gene expression, regulation, and splicing, allowing for advances in these study domains and propelling the market.
• Expanding Applications in Drug Discovery and Development NGS-based RNA-seq is increasingly being utilized in drug research and development to find new therapeutic targets and better understand drug responses at the genomic level. This application is a major driver of the RNA-seq market.

Key Challenges

• High Data Management Requirements NGS-based RNA-seq creates massive volumes of data, which presents substantial hurdles in data storage, management, and analysis. This need for sophisticated bioinformatics tools and knowledge to handle and understand data becomes a significant hurdle for smaller laboratories and research institutes, limiting market growth.
• Complexity of Sample Preparation Sample preparation for NGS-based RNA-seq is complex and error-prone, affecting the accuracy of results. This complexity demands trained staff and increases the time and expense involved with RNA sequencing initiatives, reducing market demand.
• Cost Constraints The original cost of NGS equipment and continuing expenses for reagents, maintenance, and data processing, even with NGS technology’ declining costs, remain unaffordable for certain organizations. This hinders the widespread deployment of RNA-seq in resource-constrained environments.

Key Trends

• Integration of Artificial Intelligence and Machine Learning The use of AI and ML technologies in NGS-based RNA-seq is becoming increasingly popular for efficiently managing and analyzing large amounts of data. These tools help to identify complicated patterns in gene expression data for improving research outcomes and diagnosis accuracy.
• Single-Cell RNA Sequencing (scRNA-seq) Growth Demand for single-cell RNA sequencing is quickly increasing since it allows for a more precise investigation of cellular variations and functions within a sample. This trend is fundamentally changing our understanding of biology and disease at the single-cell level.
• Multiplexing and High-Throughput Technologies Multiplexing and high-throughput sequencing technologies have made it possible to analyze many samples or genes at the same time. This increases efficiency and lowers the cost per sample, making RNA-seq more accessible and widely used in research and clinical diagnoses, promoting market expansion.
• Expansion into Clinical DiagnosticsThere is an increasing trend of using NGS-based RNA-seq in clinical diagnostics to discover and understand disorders at the genomic level. This includes applications in cancer diagnoses, infectious diseases, and genetic abnormalities, paving the path for more personalized and effective therapies.

Global NGS-based RNA-seq Market Regional Analysis

Here is a more detailed regional analysis of the NGS-based RNA-seq Market

North America

• According to Market Research, North America is estimated to dominate in NGS-based RNA-seq Market over the forecast period. North America, particularly the United States, has a strong research infrastructure, including multiple top universities, research organizations, and biotech companies. This climate promotes innovation and rapid adoption of NGS-based RNA-seq technologies, allowing the region to dominate the market
• Significant public and private investment in the healthcare and biotechnology industries in North America enables advanced research, development, and application of NGS-based RNA-seq. This financial support speeds up technical breakthroughs and their implementation in healthcare settings.
• Personalized medicine is becoming increasingly popular in North America, to tailor medical treatments to individual genetic profiles. NGS-based RNA-seq is critical for understanding genetic variants, thereby, driving its use in both research and clinical diagnostics throughout the region.
• Furthermore, the regulatory climate in North America, particularly in the United States, fosters the development and application of NGS-based technologies, thanks to the FDA’s proactive approach to genomic and precision medicine. This supporting policy framework shortens the path to market for innovative RNA-seq applications and developments.

Asia Pacific

• Asia Pacific is estimated to grow at the highest CAGR within the NGS-based RNA-seq Market during the forecast period. The region’s healthcare sector is expanding rapidly, supported by increased investment and government measures to improve healthcare infrastructure. This expansion encourages the use of modern technologies such as NGS-based RNA-seq in diagnosis and research.
• Precision medicine is becoming increasingly important in Asia Pacific countries, to provide patient-specific medicines based on genetic information. As a result of its importance in studying genetic variants, NGS-based RNA-seq is becoming increasingly popular.
• The region is experiencing an increase in the prevalence of genetic abnormalities and cancer, necessitating the use of modern diagnostic technologies. NGS-based RNA-seq provides extensive insights into genetic information, allowing for early detection and personalized treatment regimens.
• Furthermore, Asia-Pacific is emerging as a hub for biotechnology and pharmaceutical research and development. Governments and commercial organizations are increasing financing for genomics research, accelerating the expansion of NGS-based RNA-seq by providing critical resources for innovation and application in this field.

Europe

• Europe has a rich legacy of international collaborative research, which is encouraged by EU financing programs such as Horizon Europe. These efforts promote the use of NGS-based RNA-seq technologies in a variety of sectors, accelerating growth by pooling resources and expertise.
• European countries are investing more in precision medicine, with national and regional initiatives aimed at incorporating genomic data into healthcare. NGS-based RNA-seq is critical for these activities, resulting in increased application in both research and clinical diagnoses.
• The most recent genomics technology advancements are being quickly adopted by the European market. This includes NGS-based RNA-seq, which is growing and becoming more accessible across the region because of advances in sequencing efficiency, data processing, and cost reductions, driving market adoption.
• Furthermore, the biotech and pharmaceutical industries in Europe are expanding rapidly, with an emphasis on medication discovery and development using genomic data. NGS-based RNA-seq is critical for discovering new therapeutic targets and understanding disease mechanisms, driving its development in these industries.

Global NGS-based RNA-seq MarketSegmentation Analysis

The NGS-based RNA-seq Market is Segmented based on Product & Service, Technology, Application, End-user, And Geography.

NGS-based RNA-seq Market, By Product & Service

• Sample Preparation Products
• Sequencing Platforms and Consumables
• Sequencing Services
• Data Analysis, Storage and Management

Based on Product & Service, the market is segmented into Sample Preparation Products, Sequencing Platforms and Consumables, Sequencing Services, and Data Analysis, Storage & Management. The sequencing platforms and consumables segment is estimated to dominate the NGS-based RNA-seq Market due to the critical function these products play throughout the sequencing process. Sequencing platforms and consumables are critical components of RNA sequencing because they have a direct impact on the efficiency, accuracy, and throughput of the sequencing procedures. The high costs of these platforms, along with the continuous requirement for consumables, ensure that this category receives a sizable share of market income.

NGS-based RNA-seq Market, By Technology

• Sequencing by Synthesis (SBS)
• Ion Semiconductor Sequencing
• Single-molecule Real-time Sequencing
• Nanopore Sequencing

Based on Technology, the market is segmented into Sequencing by Synthesis (SBS), Ion Semiconductor Sequencing, Single-molecule Real-time Sequencing, and Nanopore Sequencing. The sequencing by synthesis (SBS) segment is estimated to grow at the highest CAGR in the NGS-based RNA-seq Market due to its widespread use in academic research and clinical diagnostics due to its high throughput, precision, and cost-effectiveness when compared with other sequencing methods. SBS, as demonstrated by Illumina’s sequencing platforms, has established the gold standard in NGS because it delivers a consistent balance of read length and sequencing depth, making it ideal for a wide range of applications, including transcriptome profiling and whole-genome sequencing.

NGS-based RNA-seq Market, By Application

• Expression Profiling Analysis
• Small RNA Sequencing
• De Novo Transcriptome Assembly
• Variant Calling and Transcriptome Epigenetics

Based on Application, the market is segmented into Expression Profiling Analysis, Small RNA Sequencing, De Novo Transcriptome Assembly, and Variant Calling & Transcriptome Epigenetics. The expression profiling analysis segment is estimated to exhibit the highest growth within the market over the forecast period due to the crucial role that expression profiling plays in understanding gene function, regulation, and the genetic basis of illness. Expression profiling analysis using NGS-based RNA-seq offers unprecedented depth and breadth in assessing the expression levels of thousands of genes at the same time, providing insights into the molecular signatures of distinct cells and tissues under varied settings.

NGS-based RNA-seq Market, By End-User

• Research and Academia
• Hospitals and Clinics
• Pharmaceutical and Biotechnology Companies
• Others

Based on End-User, the market is segmented into Research and Academia, Hospitals & Clinics, Pharmaceutical & Biotechnology Companies, and Others. The research and academia segment is estimated to grow at the highest CAGR in the market over the forecast period owing to the widespread use of NGS-based RNA sequencing in basic and applied research to get an unprecedented understanding of genomic expressions, variants, and functions. Globally, academic and research organizations make significant investments in genomic research, using RNA-seq technology to investigate difficult biological problems, disease processes, and evolutionary studies.

Key Players

The “Global NGS-based RNA-seq Market” study report will provide valuable insight with an emphasis on the global market. The major players in the market are Illumina, Thermo Fisher Scientific, Agilent Technologies, F. Hoffmann-La Roche, QIAGEN, PerkinElmer, Pacific Biosciences of California, Oxford Nanopore Technologies, Novogene Co., BGI, Macrogen, GENEWIZ, Eurofins Genomics, Twist Bioscience Corporation, MGI Tech Co., Paragon Genomics, NanoString Technologies, Lexogen, and Singular Genomics Systems.

Our market analysis also entails a section solely dedicated to such major players wherein our analysts provide an insight into the financial statements of all the major players, along with product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share, and market ranking analysis of the above-mentioned players globally.

NGS-based RNA-seq Market Recent Developments

• In February 2024, Illumina announced its new “NovaSeq X Plus” sequencing equipment, which promises quicker run times and increased throughput for single-cell RNA-seq applications. This technology is intended to be especially useful for researchers investigating intricate biological processes at the cellular level.
• In February 2024, BGI and Berry Genomics announced a collaboration to create an AI-powered platform for analyzing RNA-seq data. This platform is intended to increase the accuracy and efficiency of RNA-seq data analysis, resulting in faster and more precise diagnoses and treatment strategies.
• In February 2024, NanoString Technologies received FDA approval for its GeoMx NGS Targeted Assay, a next-generation sequencing (NGS) solution for targeted gene expression analysis. This approval opens up new avenues for applying NGS technology in clinical settings.
• In February 2024, 10x Genomics and Sema4 announced a collaboration to develop and commercialize spatial transcriptomics technologies. This cooperation seeks to combine 10x Genomics’ spatial biology knowledge with Sema4’s artificial intelligence and machine learning skills, resulting in advanced solutions for analyzing the spatial distribution of RNA in tissues.

Report Scope

Research Methodology of Market Research

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Reasons to Purchase this Report

• Qualitative and quantitative analysis of the market based on segmentation involving both economic as well as non-economic factors• Provision of market value (USD Billion) data for each segment and sub-segment• Indicates the region and segment that is expected to witness the fastest growth as well as to dominate the market• Analysis by geography highlighting the consumption of the product/service in the region as well as indicating the factors that are affecting the market within each region• Competitive landscape which incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions and acquisitions in the past five years of companies profiled• Extensive company profiles com