Global Organs-On-Chips Market Size By End User (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes), By Application (Physiological Model Development, Drug Discovery), By Type (Liver, Heart), By Geographic Scope And Forecast

Organs-On-Chips Market Valuation – 2024-2031

Growing demand for checking the efficiency, potency, and toxicity of drugs and also to reduce risks related to surgeries of vital organs there is a requirement of microengineered biomimetic systems. These growing advancements in the biotechnology sector play a crucial role in the expansion of the Organs-On-Chips Market, driving the market size. reach a valuation of USD 350 Million over the forecast 2031, surpassing the revenue of USD 178.4 Million valued in 2023. Increased funding by pharmaceutical companies and government agencies in organ-on-chips technology is projected to bolster the growth of the global Organs-On-Chips Market. Such financial support is estimated to bring about innovation in biopharmaceuticals and medical technologies and enable the market to grow at a CAGR of 30.6% from 2024 to 2031.

Organs-On-Chips MarketDefinition/ Overview

Organ-on-chips (OOCs) are small devices that replicate the form and function of human organs. Compared to traditional cell cultures, these chips—which are made of living cells and replicate the physiological circumstances of particular organs—allow researchers to examine how medications, illnesses, and other stimuli affect organs at the level of individual cells in a more precise and regulated setting. OOCs offer a more accurate and ethical alternative to animal testing for evaluating new drugs and predicting their effectiveness and potential side effects. Patient-derived cells are used to create organ-on-chips (OOCs), which allow customized medicine to anticipate unique responses to specific treatments. The course of diseases, such as cancer or Alzheimer’s, can be studied and understood using OOCs, perhaps leading to the discovery of new treatments and cures.

Which are the key drivers shaping the growth trajectory of the Organs-On-Chips Market?

Increasing ethical concerns and stringent animal welfare regulations is restraining the use of animal models for the preclinical testing of toxicity and efficacy of drugs and other biopharmaceutical products. This shift from traditional animal testing to organ-on-chip models is crucial game-changing advantage for expansion of the current market.

Growing demand for personalized or customized medicine is spurring upward due to the focus on patient-centric treatment. Meanwhile, the ongoing research and development for testing the toxicity or efficacy of a particular drug on patient’s cells is likely to shift the preference of professionals as well as customers from traditional methods to latest organ-on-chips. The exact resemblance to human organs is projected to enhance its application in the entire healthcare industry.

Also, the rising competition among top pharmaceutical companies is bolstering the demand for efficient and cost-effective means for drug development, driving demand for OOCs.. This miniature replica version of human organs is projected to help detect potential candidates early on to avoid failure in the later stages, thereby contributing toward cost savings during drug development.

With the advancements in field of cytology, integration of microfluidics, bioprinting, and stem cell technologies is projected to rise in the field of medicine.  These new technologies are helping the market grow and will lead to more effective and personalized medical treatments in the future.

Majorly, the growing demand for real-time imaging, in vitro analysis of biochemicals, and studying of genetic and metabolic activities of living cells to develop a cure for prevalent diseases will drive the market.

How will limitations in scalability and standardization fare for Organs-On-Chips Market?

Scalability and efficiency are critical aspects likely to challenge the application of organ-on-chip (OOCs) technology. The need for extensive screening of drugs that too one at a time to develop a particular tailored medicine is acting as a barrier for the growth of Organs-On-Chips Market.

High emphasis on providing aseptic and ambient conditions for the growth and efficacy of the cell lines in the invitro environment is a major factor hampering the adoption of OOC. Likewise, growing focus on standardization of protocols and regulatory norms for a smooth and cooperative research and development in the field of OOC is another factor limiting the market growth.

Need for hi-end technologies such as autoclaves, inverted microscope, incubator, centrifuge, and other basic equipment is anticipated to increase the upfront cost. As the equipment cost is skyrocketing, the manufacturing of OOCs, especially cell culture for microfluidic technology is proving difficult. This overall costing is expected to restrain the adoption of this technology by budget constrained organizations or research laboratories. In addition to all this, the complexity associated with the development of organ-on-chip technology is a major factor impeding the growth of this market.

Category-Wise Acumens

What Role does Liver-related Ailments Play in Expansion of Organs-on Chips Market?

According to Analysis, the liver-on-the-chip segment is estimated to hold the largest market share in the type segment during the forecast period. Growing inclination toward sedentary lifestyle, alcohol consumption, and smoking one of the major factors resulting in the occurrence of chronic liver disease such as liver-related ailments. Some of these diseases include liver cirrhosis, fatty liver disease, and hepatitis, which are found to affect millions of individuals worldwide. This is projected to increase the demand for drug analysis and other personalized treatments, propelling the requirement for liver-on-chip model.

The high frequency of liver disorders and the difficulty of simulating liver activities make liver-on-a-chips an important segment for promoting liver-related research and treatment development. In response to which, the need for effective drugs for the treatment is increasing the use of preclinical drug testing procedures. This is wide range acceptance on the global platform is bolstering the application of liver-on-chips segment, thriving the segment.

How are Pharmaceutical Companies Revolutionizing the Organs-On-Chips Market?

The pharmaceutical and biotechnology companies segment is estimated to dominate the Organs-On-Chips Market during the forecast period from 2024 to 2031.

Prevalence of chronic diseases coupled with ongoing research and development in the field of medical science is resulting in implementation of cutting-edge technologies like OOCs. Thus, the need for speeding up the preclinical drug analysis and drug development process to check the toxicity and efficacy of drugs during the early stages is proving cost-effective for the pharmaceutical and biotechnology companies. It is expected to enable this end user segment flourish during the forecast period.]

Additionally, the compliance of the traditional as well as existent pharmaceutical and biotechnology companies with current effective animal welfare regulations and ethical issues reduces the use of animal models. Thus, the increasing use of organ-on-chip models by these companies is a primary aspect driving the segment.

Country/Region-wise Acumens

How do Sedentary Lifestyle Changes Impact Organs-On-Chips Market in North America?

According to Analyst, North America is estimated to dominate the Organs-On-Chips Market during the forecast period. The inclination of all-aged groups toward sedentary activities, such as  gaming, watching TV, and habit bads like smoking and alcohol consumption The competition among emerging as well as prominent biopharmaceutical industry regarding the development of drug and other biopharmaceutical product, especially vaccines, monoclonal antibodies, and other is on the rise in the region. It is might be an opportunistic factor bolstering the Organs-On-Chips Market in North America.

In addition to this, the government support and funding for improving the  research and development infrastructure and activities in the field of drug development and biotechnological projects are  influencing growth in North America. A highly skilled workforce with expertise in medicinal techniques is adding to the region’s development.

The presence of prominent players including Emulate, AxoSim, Ascendance Bio, and Nortis, among others in this region is boosting the adoption of organ-on-chips in the American healthcare industry.  Furthermore, North American regulatory frameworks is actively promoting the use of alternative testing techniques, which supports the growth of the OOCs market in the region. All these factors are crucial in driving the growth of the market, thereby resulting in the dominance of the region.

Will Upfront Investment in Healthcare Infrastructure in the Asia Pacific Fuel the Organs-On-Chips Market?

Asia Pacific region is estimated to be the most opportunistic region for the Organs-On-Chips Market during the forecast period. The presence of large patient populations offers a unique opportunity for research and development and government initiatives, fueling demand for technological innovation in the healthcare sector in the region.

Another factor which is the constant onset of epidemiology and other adverse diseases is surging the demand for advancements such as organ-on-chips models, facilitating the revolutionization of the Asian healthcare industry.

Increasing disposable income and favorable reimbursement policies in the economies like China and India is shifting the focus of patients on using personalized health solutions instead of relying on the traditional means. Thus, the increasing integration of advanced technologies such sophisticated research laboratories in the healthcare facilities is likely to offer immense opportunities of growth for the Organs-On-Chips Market.

Increase in the preclinical and clinical trials in the region to develop efficient drugs for the prevalent diseases in the region is a major influencing factor for the growth of the OOCs market.  The blooming pharmaceutical business in Asia Pacific is anticipated to creative opportunities for expansion of the market over the forecast period.

Global Organs-On-Chips Market Segmentation Analysis

The Global Organs-On-Chips Market is segmented on the basis of End User, Application, Type, And Geography.

Organs-On-Chips Market, By End User

• Pharmaceutical and biotechnology companies
• Academic
• Research institutes

Based on the End User, the market is segmented into Pharmaceutical and biotechnology companies, Academic, Research institutes. The pharmaceutical and biotechnology company category contributes the most to the market. For pharmaceutical and biotech industries, this technique offers enormous promise for predicting side effects and the success of drugs and biological goods. The increased drug approval failure rates allow for the development of a complete biological data set for assessing innovative therapies and medications, as well as ensuring the safety of novel treatments, where OoC plays a crucial role. This technique is being used by several pharmaceutical and biotechnology firms to accelerate the discovery and development of novel medications. The rising usage of Organ-on-Chip technology for drug development by enterprises is one of the primary drivers of the market’s expansion.

Organs-On-Chips Market, By Application

• Drug discovery
• Toxicology research
• Physiological Model
• Other applications

Based on the Application, the market is segmented into Drug discovery, Toxicology research, Physiological Model, Other applications. Over the projected period, the drug discovery segment is predicted to contribute for the greatest revenue CAGR in the worldwide market. Drug screening is mostly used for evaluating samples quickly. Scientists and researchers use organ-on-chip culture systems to evaluate medication effects in the body. This approach also comprehensively tests medication toxicity or drug efficacy in several bodily organs. Researchers can use organs-on-chip devices to determine the potential of a given medication candidate as well as the likelihood of failure at an early stage. This element is assisting this segment’s revenue growth.

Organs-On-Chips Market, By Type

• Heart on chip
• Human on chip
• Intestine on chip
• Kidney on chip
• Liver on chip
• Lung on chip

Based on Type, the market is segmented into Heart on chip, Human on chip, Intestine on chip, Kidney on chip, Liver on chip, and Lung on chip. The lung-on-chip segment will have the greatest revenue share of the organ-on-chip market by 2022. Lung-on-chips are being developed to improve the physiological applicability of present in vitro alveolar-capillary interface models. A multifunctional microdevice of this type can mimic crucial structural, functional, and mechanical characteristics of the human alveolar-capillary interface.

Organs-On-Chips Market, By Geography

• North America
• Europe
• Asia Pacific
• Rest of the world

On the basis of Regional Analysis, The Global Organs-On-Chips Market is classified into North America, Europe, Asia Pacific, and the Rest of the world. North America is expected to account for the largest share and is also expected to grow at the highest CAGR of the market followed by Europe. The significant growth of the North American Organs-On-Chips Market is mostly due to the region’s expanding healthcare applications and cutting-edge technological advancements. The presence of top-tier researchers and scientists also contributes to the region’s industrial growth.

Moreover, the market growth is being fueled globally by the significant presence of top organ-on-chip suppliers and producers. These elements will ultimately fuel the need in the regional market for organ-on-chip products. It is projected that Asia-Pacific would increase its market share. The market in the region will increase as a result of rising disposable income among the populace and supportive government financing for regenerative medicine research institutes. The scale of the Organs-On-Chips Market will be boosted in the near future by product innovation, collaborative partnerships, and private-public strategic alliances.

Key Players

The “Global Organs-on-chips Market” study report will provide valuable insight with an emphasis on the global market including some of the major players such as BiomimX SRL, Elveflow, Hesperos, Altis Biosystems, Nortis Inc., AxoSim, Bi/ond, InSphero, Emulate Inc., Allevi Inc., MIMETAS BV, Netri, Valo Health (Tara Biosystems Inc.), TissUse GmbH., MesoBiotech, Chiron, Cherry Biotech, 4Dcell, BioIVT, AlveoliX, BEOnchip, Tissue Dynamics.

Our market analysis also entails a section solely dedicated to such major players wherein our analysts provide an insight into the financial statements of all the major players, along with its product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share, and market ranking analysis of the above-mentioned players globally.

Key Developments

• In December 2023, Emulate and Boehringer Ingelheim collaborated to use Emulate’s Human-on-a-Chip platform for preclinical drug development and testing, with a particular emphasis on liver toxicity and metabolism. This collaboration demonstrates the increasing industry usage of OOC technology by significant pharmaceutical firms.
• In December 2023, InSphero raised $45 Million to broaden its worldwide reach and market its organ-specific technology for drug development and disease modelling. The growing interest in OOC solutions for applications in customized medicine is demonstrated by this investment.
• In November 2023, 4Dcell collaborated with the University of Pittsburgh to create a sophisticated platform that mimics the interactions between kidney, liver, and heart tissues. Through consideration of inter-organ communication, this cooperation seeks to enhance preclinical drug safety and efficacy testing.

Ace Matrix Analysis

The Ace Matrix provided in the report would help to understand how the major key players involved in this industry are performing as we provide a ranking for these companies based on various factors such as service features & innovations, scalability, innovation of services, industry coverage, industry reach, and growth roadmap. Based on these factors, we rank the companies into four categories as Active, Cutting Edge, Emerging, and Innovators.

Market Attractiveness

The image of market attractiveness provided would further help to get information about the region that is majorly leading in the Organs-On-Chips Market. We cover the major impacting factors that are responsible for driving the industry growth in the given region.

Porter’s Five Forces

The image provided would further help to get information about Porter’s five forces framework providing a bl