Parkinson’s Disease Drugs Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented by Mechanism of Action (Dopamine Agonists, Anticholinergic, MAO-B Inhibitors, Amantadine, Carbidopa-levodopa, COMT Inhibitors, and Other Mechanisms of Action), By Distribution Channel (Retail Pharmacies, Hospital Pharmacies, Others), By Region, and Competition
Published Date: November - 2024 | Publisher: MIR | No of Pages: 320 | Industry: Healthcare | Format: Report available in PDF / Excel Format
View Details Buy Now 2890 Download Sample Ask for Discount Request CustomizationParkinson’s Disease Drugs Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented by Mechanism of Action (Dopamine Agonists, Anticholinergic, MAO-B Inhibitors, Amantadine, Carbidopa-levodopa, COMT Inhibitors, and Other Mechanisms of Action), By Distribution Channel (Retail Pharmacies, Hospital Pharmacies, Others), By Region, and Competition
| Forecast Period | 2024-2028 |
| Market Size (2022) | 4.80 billion |
| CAGR (2023-2028) | 7.50% |
| Fastest Growing Segment | Hospital Pharmacies |
| Largest Market | North America |
Market Overview
Global Parkinson’s Disease Drugs Market has valued at USD 4.80 billion in 2022 and is anticipated to witness an impressive growth in the forecast period with a CAGR of 7.50% through 2028. Parkinson's disease is a chronic and progressive neurodegenerative disorder of the central nervous system that primarily affects movement control. It is characterized by a range of motor symptoms and can also involve non-motor symptoms. Resting tremors are a hallmark symptom of Parkinson's disease. These involuntary shaking movements typically occur when the affected limb is at rest and often involve a rhythmic "pill-rolling" motion of the fingers. Muscle stiffness and increased resistance to passive movement are common in Parkinson's disease. This rigidity can affect various muscle groups and lead to a sense of physical discomfort. Balance problems and a tendency to fall can develop as Parkinson's disease progresses. Individuals may have difficulty maintaining an upright posture and may experience unexplained falls. Parkinson's disease can involve a range of non-motor symptoms, including mood changes (such as depression and anxiety), sleep disturbances, cognitive impairment, autonomic dysfunction (such as constipation and orthostatic hypotension), and sensory changes.
Parkinson's disease is becoming more common, with a growing number of diagnosed cases globally. This trend increases the need for effective pharmaceutical treatments. Pharmaceutical companies are investing in research and development to create more effective and innovative drugs for Parkinson's disease. This includes developing drugs that not only alleviate symptoms but also potentially slow the progression of the disease. Greater awareness of Parkinson's disease among healthcare professionals and the public has led to earlier diagnosis and treatment. This drives the demand for drugs to manage the condition. Beyond traditional treatments, there is growing interest in emerging therapies, such as gene therapies, stem cell therapies, and neuroprotective agents. These therapies offer the potential for disease modification, further driving the market.
Key Market Drivers
Advancements in Technology
Implantable or wearable devices that deliver medication continuously or on-demand have been developed. These devices can provide a more stable and consistent drug delivery, reducing motor fluctuations and the need for frequent dosing. Advances in drug formulation techniques have led to the development of extended-release and controlled-release formulations. These formulations can help maintain therapeutic drug levels in the body over an extended period, reducing the frequency of medication administration. Inhalable levodopa formulations have been developed to provide rapid relief of motor symptoms. These inhalers can be particularly beneficial for patients who experience sudden "off" periods. Research is ongoing to identify and develop neuroprotective drugs that may slow the progression of Parkinson's disease. These drugs aim to protect and preserve dopamine-producing neurons in the brain. Advances in genetic testing and biomarker identification are enabling more personalized treatment approaches. Tailoring medication regimens to an individual's genetic profile and disease stage can optimize treatment outcomes. Prodrugs are inactive compounds that convert into active drugs within the body. Some prodrugs have been designed to improve the delivery of levodopa, the primary treatment for PD, and reduce side effects.
Non-invasive focused ultrasound is being explored as a potential treatment for PD. This technology can be used to target and disrupt brain regions responsible for tremors and other motor symptoms. Deep Brain Stimulation (DBS) is a surgical procedure that involves implanting electrodes in the brain to modulate neural activity. Ongoing technological improvements in electrode design and stimulation techniques aim to enhance the effectiveness of DBS as a treatment option. The integration of telemedicine and remote monitoring technologies allows healthcare providers to monitor patients' symptoms and adjust medication regimens remotely, improving patient care and reducing the need for frequent in-person visits. Artificial intelligence and machine learning algorithms are being employed to analyze data from wearable devices and sensors to track disease progression and predict "off" periods, enabling more proactive medication adjustments. Virtual Reality (VR) -based rehabilitation programs are being developed to improve motor function and balance in PD patients. These technologies provide interactive and engaging exercises. This factor will help in the development of Global Parkinson’s Disease Drugs Market.
Rising Disease Prevalence
Parkinson's disease primarily affects older individuals. As the global population ages, there is a natural increase in the number of people at risk for developing Parkinson's disease. This demographic shift is a major driver of the rising prevalence. Advances in healthcare and improved living conditions have increased life expectancy worldwide. With people living longer, the risk of developing age-related neurodegenerative diseases like Parkinson's increases. Greater awareness of Parkinson's disease among healthcare professionals and the public has led to earlier and more accurate diagnoses. Improved diagnostic criteria and access to healthcare services have contributed to a higher number of reported cases. The overall growth of the world's population also plays a role. A larger population means a larger pool of individuals at risk for Parkinson's disease. Some studies suggest that environmental factors, such as exposure to pesticides and industrial chemicals, may contribute to the risk of developing Parkinson's disease. Changes in environmental conditions and increased urbanization could impact disease prevalence.
While Parkinson's disease is not purely genetic, certain genetic mutations and family history can increase the risk of developing the disease. As genetic testing becomes more accessible, more individuals at risk may be identified. Public health campaigns and educational initiatives have encouraged more people to seek medical attention for early signs of Parkinson's disease. Screening programs and outreach efforts can lead to earlier detection. Changes in lifestyle and dietary habits, including factors like obesity and exposure to certain toxins, can influence the risk of developing Parkinson's disease. These trends can vary by region and contribute to differences in disease prevalence. Improvements in healthcare infrastructure and access to medical services, especially in developing regions, mean that more people can receive a Parkinson's diagnosis and treatment. Parkinson's disease research and advocacy organizations have worked to raise awareness about the condition and push for increased funding and resources for research, which has led to improved understanding and diagnosis of the disease. This factor will pace up the demand of Global Parkinson’s Disease Drugs Market.
Emerging Therapies
Emerging therapies in Parkinson's disease are innovative approaches that aim to provide more effective treatment options, potentially slow disease progression, and improve the overall quality of life for individuals living with this neurodegenerative condition. Gene therapy involves altering or replacing faulty genes to treat or prevent disease. In Parkinson's disease, researchers are exploring gene therapy approaches to enhance the production of dopamine or protect dopamine-producing neurons. Promising targets include the GDNF (glial cell-derived neurotrophic factor) gene. Stem cell therapies aim to replace damaged or lost dopamine-producing neurons in the brain. Researchers are investigating the use of various stem cell types, including induced pluripotent stem cells (iPSCs) and embryonic stem cells, to generate dopamine neurons for transplantation. Several drugs and compounds are under investigation for their potential to protect and preserve dopamine-producing neurons in the brain. These agents may have disease-modifying effects and slow the progression of Parkinson's disease. Alpha-synuclein is a protein that forms abnormal aggregates in the brains of individuals with Parkinson's disease. Therapies aimed at reducing alpha-synuclein aggregation or clearing existing aggregates are being explored as potential disease-modifying treatments. Inflammation in the brain is thought to play a role in the progression of Parkinson's disease. Immunotherapies and anti-inflammatory drugs are being investigated to determine if they can slow disease progression or reduce symptoms. Non-invasive focused ultrasound is being studied as a potential treatment for Parkinson's disease. It can be used to target and disrupt brain regions responsible for tremors and other motor symptoms.
Optogenetics is a cutting-edge technique that involves using light-sensitive proteins to control the activity of specific neurons in the brain. Researchers are exploring optogenetic approaches to modulate neural circuits involved in Parkinson's symptoms. Tau protein abnormalities have been associated with Parkinson's disease. Emerging therapies targeting tau protein aggregates are being investigated as potential disease-modifying treatments. Advances in biomarker research may lead to the development of therapies tailored to specific subtypes of Parkinson's disease. These therapies aim to target the underlying molecular mechanisms of the disease. Neurofeedback and Brain-Computer Interfaces (BCIs) are being explored to assist patients in regaining control over their movements and alleviate Parkinson's symptoms. These technologies provide real-time feedback and assist in motor rehabilitation. Tailoring treatment regimens to an individual's genetic profile and disease stage is a growing focus in Parkinson's disease management. Precision medicine approaches aim to optimize therapy for each patient's specific needs. Nanotechnology may offer novel drug delivery methods, such as nanoparticles that can target specific brain regions or deliver therapeutic agents more effectively to the brain. This factor will accelerate the demand of Global Parkinson’s Disease Drugs Market.
Key Market Challenges
Side Effects and Tolerability
Some Parkinson's disease drugs, particularly levodopa, can lead to motor fluctuations, including "on-off" periods, dyskinesias (involuntary movements), and wearing-off phenomena. These fluctuations can be disruptive and challenging to manage. Many Parkinson's drugs can cause gastrointestinal side effects such as nausea, vomiting, and constipation. These side effects can affect medication absorption and patient compliance. Dopaminergic medications, including dopamine agonists, can lead to psychiatric side effects like hallucinations, impulse control disorders, and mood disturbances. These can have a significant impact on a patient's mental well-being. Some medications may exacerbate cognitive impairment in Parkinson's disease patients, particularly in advanced stages of the disease. This can include impairments in memory, attention, and executive function. Parkinson's disease drugs can lower blood pressure, leading to orthostatic hypotension, a condition where blood pressure drops significantly upon standing. This can result in dizziness, falls, and fainting. Medications can affect sleep patterns, leading to insomnia or excessive daytime sleepiness. Sleep disturbances can further worsen the quality of life for patients. Dopamine agonists can sometimes cause impulsive behaviors, including gambling and hypersexuality. These behaviors can strain relationships and have financial and social consequences. Patients with Parkinson's disease often take multiple medications to manage their symptoms and comorbid conditions. Drug interactions can occur, potentially leading to adverse effects or reduced drug efficacy.
Limited Efficacy of Current Treatments
Over time, many patients with Parkinson's disease experience motor fluctuations, characterized by periods of "on" (when medication is working well) and "off" (when medication is less effective). These fluctuations can lead to unpredictable symptom changes and reduced quality of life. Levodopa, a common dopaminergic medication used in Parkinson's disease treatment, can lose its effectiveness over time. Patients may require higher doses, leading to increased risk of side effects. Parkinson's disease is associated with a range of non-motor symptoms, including cognitive impairment, depression, anxiety, sleep disturbances, and autonomic dysfunction. Current treatments often provide limited relief for these non-motor symptoms. While existing drugs can manage symptoms, they do not address the underlying neurodegenerative process that causes Parkinson's disease. As the disease progresses, patients may become less responsive to medication, and symptoms may worsen. Some patients develop tolerance to dopaminergic medications, leading to reduced effectiveness. Moreover, long-term use of these drugs can result in dyskinesias (involuntary movements) that are challenging to manage. Current treatments may not adequately address cognitive impairment, which can be a significant challenge for patients and caregivers.
Key Market Trends
Patient-Centric Approaches
Recognizing that Parkinson's disease can manifest differently in each patient, healthcare providers are increasingly tailoring treatment plans to the specific needs and characteristics of individuals. Genetic testing and other biomarker assessments may be used to determine the most appropriate medications and dosages. Patient-centric care emphasizes the importance of involving patients in their own care decisions. It considers their preferences, values, and goals when developing treatment plans. This approach fosters a collaborative relationship between patients and healthcare providers. Shared decision-making is a fundamental aspect of patient-centric care. It involves a two-way exchange of information and decision-making between patients and healthcare providers to determine the most suitable treatment options based on the patient's preferences and circumstances. Educating patients about their condition, treatment options, and self-management strategies is crucial. Empowering patients with knowledge enable them to actively participate in their care and make informed decisions. A patient-centric approach often involves a multidisciplinary care team, including neurologists, physical therapists, occupational therapists, speech therapists, and mental health professionals. This team collaborates to address the diverse needs of Parkinson's patients.
Segmental Insights
Mechanism of Action Insights
In 2022, the Global Parkinson’s Disease Drugs Market largest share was dominated by MAO-B inhibitors segment in the forecast period and is predicted to continue expanding over the coming years.
Distribution Channel Insights
In 2022, the Global Parkinson’s Disease Drugs Market largest share was dominated by hospital pharmacies segment in the forecast period and is predicted to continue expanding over the coming years.
Regional Insights
The North America region dominates the Global Parkinson’s Disease Drugs Market in 2022.
Recent Developments
- In August 2023, The FDA has approved Aspen Neuroscience'sapplication for an Investigational New Drug (IND) for a new Parkinson's Diseasegene treatment, the company reported. The company is now free to start clinicaltrials thanks to this clearance. The medication aims to restore damaged neuronalcells in Parkinson's disease sufferers. The three parts of the therapy processare described in the news release. A small sample of the patient's stem cellsis first taken by the medical staff.
- In May 2022, For the treatment of motorfluctuations in patients with advanced Parkinson's disease (PD), AbbVie hassubmitted a New Drug Application (NDA) to the U.S. Food and Drug Administration(FDA) for ABBV-951 (foscarbidopa/foslevodopa). The goal of ABBV-951 is to offera unique, continuous, 24-hour subcutaneous delivery of CD/LD. It provides thepotential for improvement in motor fluctuations in patients with advancedParkinson's disease, a chronic, progressive neurological disorder caused by theloss of dopamine-producing brain cells.1 Parkinson's disease is primarilycharacterized by tremor, muscle rigidity, sluggish movement, and balanceissues. In Parkinson's disease (PD), patients and their healthcareprofessionals have the same objectiveto increase the amount of "On"time, which refers to the time when symptoms are well-controlled and free ofdyskinesia or uncontrollable movements.
- In January 2022, to developand commercialise ABL301, a pre-clinical stage bispecific antibody targetingalpha-synuclein and IGF1R to treat Parkinson's disease and other potentialindications with enhanced blood-brain barrier (BBB) penetration, ABL Bio, Inc.,a clinical-stage biotech developing bispecific antibody technology forimmuno-oncology and neurodegenerative diseases, announced an exclusivecollaboration and worldwide licence agreement with SANOFI. The worldwide exclusive rights to develop and market ABL301 will go toSANOFI. ABL301's preclinical development and Phase 1 clinical trial will beoverseen by ABL. The subsequent clinical development, regulatory approval, andglobal commercialization of ABL301 will be handled by SANOFI. An anti-alpha-synuclein antibody and Grabody-B, a BBB-penetratingshuttle that targets the insulin-like growth factor 1 receptor (IGF1R), arecombined to form the bispecific antibody known as ABL301. For the treatment ofsynucleinopathies, such as Parkinson's disease, it is being developed as apotential first-in-class bispecific antibody therapy.
Key Market Players
- Amneal Pharmaceuticals LLC
- AbbVie Inc.
- Boehringer Ingelheim InternationalGmbH
- GSK plc
- Teva PharmaceuticalsIndustries Ltd
- Pfizer Inc.
- Novartis AG
- F. Hoffmann-La Roche Ltd
- Kissei Pharmaceutical Co.,Ltd.
- AstraZeneca Plc
- Prevail Therapeutics Inc.
- Newron Pharmaceuticals SPA
| By Mechanism of Action | By Distribution Channel | By Region |
| · Dopamine Agonists · Anticholinergic · MAO-B Inhibitors · Amantadine · Carbidopa-levodopa · COMT Inhibitors · Other Mechanisms of Action | · Retail Pharmacies · Hospital Pharmacies · Others | · North America · Asia-Pacific · Europe · South America · Middle East & Africa |
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