Biopharmaceutical Fermentation System Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By Product Type (Upstream Products (Bioreactors/Fermentors, Bioprocess Analyzers, Process Monitoring System, Others), Downstream Products (Filtration & Separation, Chromatography, Consumables and Accessories, Others)), By Application (Antibiotics, Recombinant Proteins,
Published Date: November - 2024 | Publisher: MIR | No of Pages: 320 | Industry: Healthcare | Format: Report available in PDF / Excel Format
View Details Buy Now 2890 Download Sample Ask for Discount Request CustomizationBiopharmaceutical Fermentation System Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By Product Type (Upstream Products (Bioreactors/Fermentors, Bioprocess Analyzers, Process Monitoring System, Others), Downstream Products (Filtration & Separation, Chromatography, Consumables and Accessories, Others)), By Application (Antibiotics, Recombinant Proteins,
| Forecast Period | 2024-2028 |
| Market Size (2022) | USD 24.94 billion |
| CAGR (2023-2028) | 8.30% |
| Fastest Growing Segment | Antibiotics |
| Largest Market | North America |
Market Overview
Global Biopharmaceutical Fermentation System Market has valued at USD 24.94 billion in 2022 and is anticipated to project impressive growth in the forecast period with a CAGR of 8.30% through 2028. The global biopharmaceutical fermentation system market is a critical segment of the biotechnology and pharmaceutical industries. Biopharmaceuticals, which include therapeutic proteins, antibodies, vaccines, and other biologically derived drugs, have gained prominence in recent years due to their effectiveness in treating various diseases.
Key Market Drivers
Rising Demand for Biopharmaceuticals
The global biopharmaceutical fermentation system market is on an upward trajectory, and one of the key drivers behind this growth is the rising demand for biopharmaceuticals. Biopharmaceuticals, including monoclonal antibodies, vaccines, gene therapies, and other biologically derived drugs, have been at the forefront of medical innovation.
Biopharmaceuticals represent a revolution in healthcare. Unlike traditional chemical drugs, biologics are derived from living organisms and are highly targeted and effective. They have demonstrated remarkable success in treating a wide range of diseases, including cancer, autoimmune disorders, and rare genetic conditions. As a result, the demand for biopharmaceuticals has soared.
The global population is aging, and with age comes an increased susceptibility to chronic diseases. Biopharmaceuticals offer hope for patients suffering from conditions like diabetes, rheumatoid arthritis, and Alzheimer's disease. The prevalence of these diseases is driving up the demand for biopharmaceuticals, which, in turn, boosts the need for efficient fermentation systems.
Emerging markets, particularly in Asia-Pacific and Latin America, are witnessing a surge in demand for biopharmaceuticals. These regions are experiencing economic growth, improved healthcare infrastructure, and an increasing middle-class population. As healthcare access improves, so does the demand for advanced biologics, thus driving the demand for fermentation systems.
Advancements in Biotechnology
The global biopharmaceutical fermentation system market has been experiencing remarkable growth, thanks in large part to the continuous advancements in biotechnology. Biopharmaceuticals, including monoclonal antibodies, gene therapies, vaccines, and other biologically derived drugs, have revolutionized healthcare.
Cell culture is a cornerstone of biopharmaceutical production. Innovations in cell culture techniques, such as the development of high-yield cell lines and optimized media formulations, have significantly increased the productivity of bioreactors. As a result, biopharmaceutical companies require more advanced fermentation systems to harness these improvements.
Continuous bioprocessing is emerging as a game-changer in biopharmaceutical manufacturing. This approach offers increased productivity and efficiency compared to traditional batch processing. Advancements in continuous bioprocessing technologies are driving the adoption of fermentation systems capable of supporting these novel processes.
Technological Innovation
The global biopharmaceutical fermentation system market is experiencing unprecedented growth, largely driven by continuous technological innovation. Biopharmaceuticals, including monoclonal antibodies, vaccines, gene therapies, and other biologically derived drugs, have transformed the healthcare landscape.
Single-use bioreactors represent a significant technological advancement. These disposable systems reduce the risk of contamination, minimize downtime between batches, and streamline cleaning and validation processes. The adoption of single-use bioreactors is on the rise, driving market growth.
Continuous bioprocessing technologies are gaining traction in biopharmaceutical manufacturing. These systems allow for uninterrupted production and can significantly increase productivity. As the industry embraces continuous bioprocessing, the demand for fermentation systems supporting this approach grows.
Biopharmaceutical Outsourcing
The global biopharmaceutical fermentation system market is poised for remarkable growth, thanks in no small part to the increasing trend of biopharmaceutical outsourcing. Biopharmaceuticals, including monoclonal antibodies, gene therapies, vaccines, and more, have become pivotal in modern healthcare.
CMOs are dedicated experts in biopharmaceutical production. They offer specialized skills and knowledge that allow pharmaceutical companies to tap into a wealth of experience. As CMOs expand their services, they invest heavily in fermentation systems to meet the growing needs of their clients.
By outsourcing biopharmaceutical production, pharmaceutical companies can concentrate on their core competencies, such as drug discovery and marketing. This strategic approach has driven the demand for outsourcing services, further boosting the market for fermentation systems.
CMOs are often more cost-effective than in-house production, as they can take advantage of economies of scale and operational efficiency. To maintain this cost advantage, CMOs invest in modern fermentation systems that improve productivity and reduce production costs.
Key Market Challenges
High Initial Capital Investment
Setting up a biopharmaceutical fermentation facility requires substantial capital investment. Bioreactors, fermentation tanks, and associated equipment are expensive. Smaller companies and startups may find it challenging to make these initial investments, limiting their ability to enter the market.
Contamination Risk
Biopharmaceutical fermentation processes are highly susceptible to contamination. Even minor contaminations can lead to the loss of entire production batches. Maintaining sterile conditions throughout the process is crucial but challenging and costly.
Scalability Issues
Scaling up biopharmaceutical production is not always straightforward. Many biopharmaceutical fermentation systems face challenges in maintaining consistent product quality and yields when transitioning from small-scale research and development to large-scale production.
Raw Material Supply Chain
The availability and quality of raw materials, such as cell culture media and reagents, can impact biopharmaceutical production. Supply chain disruptions, variations in raw material quality, and dependence on a limited number of suppliers can create vulnerabilities.
Key Market Trends
Single-Use Bioreactors Revolution
Single-use bioreactors have gained immense popularity in recent years due to their flexibility, reduced risk of contamination, and cost-effectiveness. The trend towards single-use technology is expected to continue, with more biopharmaceutical manufacturers adopting these systems for their scalability and efficiency.
Continuous Bioprocessing Adoption
Continuous bioprocessing is gaining traction in biopharmaceutical manufacturing due to its potential to reduce production costs, increase productivity, and improve product quality. The adoption of continuous processing technologies is expected to rise, leading to the development of fermentation systems designed to support this approach.
Advanced Control Systems and Automation
Automation and advanced control systems are becoming integral to biopharmaceutical fermentation. These technologies enable real-time monitoring and control of critical parameters, leading to improved product consistency and reduced human error. The integration of artificial intelligence (AI) and machine learning will further enhance process optimization.
Sustainability and Green Bioprocessing
Sustainability is a growing concern in biopharmaceutical manufacturing. Companies are exploring ways to reduce the environmental impact of bioprocessing. This includes developing greener production processes and minimizing waste. Fermentation systems that align with sustainability goals, such as those designed for recycling and reduced resource consumption, will gain prominence.
Segmental Insights
Product Type Insights
Based on the category of Product Type, the downstream products are expected to dominate the overall market revenue in 2022. In the downstream products, the chromatography segment anticipates a substantial CAGR during the projected period. This growth is driven by factors such as the increasing demand for innovative biopharmaceutical drugs and the introduction of new product offerings.
Chromatography is utilized to separate molecules based on their size, charge, hydrophobicity, and specific ligand binding properties. The selection of chromatography type is determined by the physical and chemical characteristics of the fermentation products. For instance, reversed-phase high-performance liquid chromatography (HPLC) is employed for purifying recombinant human insulin and separating insulin variants from various species.
Moreover, the continuous technological advancements in chromatography techniques are expected to drive higher adoption rates within the biopharmaceutical industry, further propelling the growth of this segment. As an illustration, in January 2021, Cytiva enhanced fiber chromatography technology with the launch of HiScreen Fibro PrismA, a product designed for early monoclonal antibody (mAb) purification process development.
Application Insights
The Antibiotics segment is poised to claim a substantial market share in the Global Biopharmaceutical Fermentation System Market during the forecast period for several compelling reasons.
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Regional Insights
In the Global Biopharmaceutical Fermentation Market, North America is anticipated to assert its dominance throughout the forecast period. This expected leadership position can be attributed to several pivotal factors, including the rising demand for biotechnology-based pharmaceuticals, an upsurge in research and development endeavors, and substantial investments in the advancement of biopharmaceutical fermentation technologies. Furthermore, the increasing prevalence of chronic illnesses has driven the consumption of medicines, consequently propelling the growth of the biopharmaceutical industry. This, in turn, generates substantial opportunities for market players, as the demand for biologics and biotech drugs continues to rise, further underscoring the significance of biopharmaceutical fermentation.
The mounting demand for biopharmaceutical fermentation in the biopharmaceutical sector, driven by its potential to reduce drug toxicity and bacterial resistance while enhancing drug efficacy, has attracted numerous companies to engage in research and development initiatives centered around biopharmaceutical fermentation. For example, in August 2022, the United States' National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) allocated funding amounting to USD 15.8 million for 14 new projects encompassing technology innovation and workforce development. These projects aim to address crucial opportunities for innovation within the biopharmaceutical sector.
Additionally, the increasing prevalence of diseases such as diabetes, rheumatoid arthritis, and cancer in the region contributes significantly to the market's growth. Biopharmaceutical fermentation plays a pivotal role in manufacturing biotech and biological drugs to combat these conditions. As an illustration, as of 2021, approximately 32 million people in the United States and 14 million in Mexico were grappling with diabetes, and these numbers are projected to rise to 36.2 million and 21.8 million by 2045, respectively. Moreover, in 2022, about 1.9 million individuals in the United States were diagnosed with cancer, as per statistics from the American Cancer Society. This heightened disease burden underscores the need for effective biological drugs, thereby fueling market growth.
Furthermore, the increasing focus of companies on deploying diverse business strategies such as product launches, approvals, fundraising, and partnerships to expand their presence in the biopharmaceutical industry is expected to be a driving force behind market growth. For instance, in February 2022, Kerry Group plc completed the acquisition of Enmex S.A., a Mexican-based enzyme manufacturer, for EUR 62 million. This strategic move enhances Kerry's capabilities in enzyme engineering, fermentation, and bioprocess development. Additionally, in September 2021, Thermo Fisher Scientific announced its plans to expand its Nashville, Tenn. site by establishing a dedicated single-use technology manufacturing facility, effectively doubling its capacity. This expansion is expected to incorporate large-scale bioreactors for the production of biological drugs.
Recent Developments
- InDecember 2022, MilliporeSigma completed the acquisition of Erbi Biosystems, aMassachusetts-based company renowned for its 2 ml micro-bioreactor platformtechnology, referred to as the Breez. This strategic acquisition furtherbolsters MilliporeSigma's upstream portfolio in the field of therapeuticproteins. It empowers the company to facilitate scalable cell-based perfusionbioreactor processes spanning from 2ml to 2000L, offering swift lab-scaleprocess development capabilities.
- Similarly,in October 2022, Froilabo (Japan) unveiled a new range of fully automatedlaboratory-scale bioreactors. These bioreactors, which complement theirexisting lineup of temperature-controlled laboratory equipment, present a broadspectrum of potential applications for academic institutions, researchendeavors, process development and optimization, scale-up activities, as wellas manufacturing processes.
Key Market Players
- Agilent Technologies, Inc.
- Thermo Fisher Scientific Inc
- Lonza Group AG
- SartoriusStedim Biotech GmbH
- EppendorfSE
- DanaherCorp
- FHoffmann-La Roche AG
- Nova Biomedical Corp
- Merck KGaA
- Becton Dickinson & Co
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