Targeted Sequencing And Resequencing Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Technology (Sequencing, Re-sequencing( Electrophoresis-based resequencing, NGS, Array-based resequencing)), By Type (DNA-based targeted sequencing, RNA-based targeted sequencing), By Application (Clinical application, Plant and animal sciences, Drug development, Others), By En

Market Overview

Global Targeted Sequencing And Resequencing Market

The global targeted sequencing and resequencing market has experienced robust growth in recent years, propelled by the burgeoning adoption of next-generation sequencing (NGS) technologies and a rising emphasis on personalized healthcare solutions. Targeted sequencing involves selectively sequencing specific regions of interest within the genome, offering enhanced efficiency and cost-effectiveness compared to whole-genome sequencing. On the other hand, resequencing involves the comparison of an individual's genome to a reference genome, facilitating the detection of genetic variations associated with diseases or traits.

Key Market Drivers

Rising Investments in Precision Medicine is Driving the Global Targeted Sequencing And Resequencing Market

Precision medicine, a groundbreaking approach that tailors medical treatment to individual characteristics, is revolutionizing healthcare. At the forefront of this revolution is targeted sequencing and resequencing, technologies that allow for the precise analysis of genetic information. As investments in precision medicine soar, the global targeted sequencing and resequencing market is experiencing unprecedented growth. Precision medicine represents a paradigm shift in healthcare, moving away from the traditional one-size-fits-all approach to treatments and diagnostics. By leveraging advances in genomics, proteomics, and other omics technologies, precision medicine seeks to understand the unique genetic makeup of each patient and tailor medical interventions accordingly. This personalized approach holds the promise of more effective treatments with fewer side effects, ultimately improving patient outcomes.

At the heart of precision medicine lies the ability to accurately sequence and analyze the genome. Targeted sequencing and resequencing are powerful techniques that enable researchers and clinicians to examine specific regions of the genome with unparalleled precision. Targeted sequencing focuses on sequencing predetermined regions of interest, such as genes associated with specific diseases or drug responses. Resequencing, on the other hand, involves comparing an individual's genome to a reference genome to identify variations or mutations.

Growing Demand for Research Tools and Services is Driving the Global Targeted Sequencing And Resequencing Market

Genomic research has become integral to various scientific disciplines, including healthcare, agriculture, forensics, and evolutionary biology. The ability to sequence and analyze specific regions of the genome with high accuracy and efficiency has revolutionized our understanding of genetic variations, disease mechanisms, and evolutionary relationships. Targeted sequencing and resequencing techniques, such as polymerase chain reaction (PCR) amplification, hybridization capture, and amplicon sequencing, have significantly contributed to advancing genomic studies by allowing researchers to focus on specific regions of interest.

With the growing emphasis on personalized medicine, there is an increasing need to identify genetic variants associated with diseases, drug responses, and treatment outcomes. Targeted sequencing facilitates the identification of relevant genetic markers with high specificity and sensitivity, paving the way for tailored therapeutic interventions. Cancer is a genetically heterogeneous disease characterized by complex molecular alterations. Targeted sequencing enables comprehensive profiling of cancer genomes, leading to the discovery of driver mutations, assessment of tumor heterogeneity, and identification of potential therapeutic targets. As precision oncology gains traction, the demand for targeted sequencing in cancer research and clinical diagnostics continues to rise.

In agriculture, targeted sequencing plays a crucial role in crop improvement, livestock breeding, and biodiversity conservation. By analyzing specific genomic regions associated with desirable traits such as yield, disease resistance, and nutritional content, researchers can accelerate the development of genetically superior crops and livestock breeds, contributing to global food security and sustainability. Rapid and accurate detection of pathogens is essential for disease surveillance, outbreak investigation, and public health response. Targeted sequencing enables the selective amplification and sequencing of microbial genomes, facilitating the identification and characterization of infectious agents, including bacteria, viruses, and parasites. This capability is particularly valuable in monitoring emerging infectious diseases and tracking transmission dynamics.

Key Market Challenges

Data Analysis and Interpretation

Another significant hurdle in the global targeted sequencing and resequencing market is the complexity of data analysis and interpretation. The massive amount of sequencing data generated from these techniques requires sophisticated bioinformatics tools and expertise to extract meaningful insights. Analyzing sequencing data involves various steps, including read alignment, variant calling, and annotation, each of which presents its own set of challenges.

To address this issue, there is a growing demand for user-friendly bioinformatics software that can streamline data analysis workflows and provide actionable results. Additionally, there is a need for specialized training programs and workshops to educate researchers and clinicians on best practices for data analysis and interpretation.

Standardization and Quality Control

Ensuring the accuracy and reproducibility of sequencing results is crucial for the success of targeted sequencing and resequencing applications, particularly in clinical settings where decisions regarding patient care may be based on sequencing data. However, achieving consistent results across different sequencing platforms and laboratories remains a significant challenge due to the lack of standardized protocols and quality control measures.

Industry organizations and regulatory agencies play a vital role in addressing this challenge by developing guidelines and standards for sample preparation, sequencing protocols, and data analysis pipelines. Additionally, the implementation of rigorous quality control measures, such as regular performance monitoring and proficiency testing, can help ensure the reliability of sequencing results.

Key Market Trends

Technological Advancements

In recent years, the field of genomics has witnessed a rapid evolution, driven largely by advancements in sequencing technologies. One of the most significant developments in this realm is targeted sequencing and resequencing, which allows researchers to focus on specific regions of the genome with high precision and accuracy. This technology has revolutionized various aspects of genetic research, including disease diagnosis, drug discovery, and personalized medicine. As a result, the global targeted sequencing and resequencing market is experiencing substantial growth, propelled by the increasing demand for efficient and cost-effective genomic analysis tools.

Targeted sequencing involves the selective amplification and sequencing of specific regions of interest within the genome. This approach offers several advantages over whole-genome sequencing, including reduced costs, faster turnaround times, and higher sequencing depth, leading to greater sensitivity for detecting genetic variations. By targeting only relevant genomic regions, researchers can efficiently interrogate specific genes or genomic regions associated with particular diseases or traits.

Resequencing, on the other hand, involves the comparison of an individual's genome to a reference genome to identify genetic variations, such as single nucleotide polymorphisms (SNPs), insertions, deletions, and structural variants. This enables researchers to study genetic diversity within populations, identify disease-causing mutations, and understand the genetic basis of complex traits.

The growing adoption of targeted sequencing and resequencing technologies can be attributed to several factors. Firstly, advancements in sequencing platforms, such as next-generation sequencing (NGS) and third-generation sequencing technologies, have significantly enhanced the speed, accuracy, and cost-effectiveness of genomic analysis. These platforms offer higher throughput, increased read lengths, and improved sequencing chemistry, allowing researchers to generate large volumes of sequencing data with unprecedented accuracy and resolution.

Furthermore, the development of innovative library preparation methods, sequencing chemistries, and bioinformatics tools has further streamlined the targeted sequencing and resequencing workflow, making it more accessible to researchers with diverse backgrounds and expertise. Additionally, collaborations between academia, industry, and government agencies have facilitated the translation of genomic research findings into clinical applications, driving the adoption of targeted sequencing and resequencing in healthcare settings.

The applications of targeted sequencing and resequencing are vast and encompass various fields, including medical genetics, oncology, agriculture, and forensics. In medical genetics, targeted sequencing is used for the diagnosis of inherited diseases, pharmacogenomics, and prenatal screening. In oncology, targeted sequencing plays a crucial role in identifying somatic mutations associated with cancer development, predicting treatment response, and monitoring disease progression. In agriculture, targeted sequencing is utilized for crop improvement, trait mapping, and biodiversity conservation. In forensics, targeted sequencing is employed for human identification, paternity testing, and forensic DNA analysis.

Segmental Insights

Technology Insights

Based

Application Insights

The Clinical application segment is projected to experience rapid growth during the forecast period. Targeted sequencing enables precise analysis of specific genomic regions associated with diseases. This capability is pivotal in advancing precision medicine initiatives, where treatments are tailored to individual genetic profiles. As precision medicine gains prominence, the demand for targeted sequencing in clinical settings escalates. Targeted sequencing facilitates accurate diagnosis of genetic disorders and provides insights into disease risk assessment. Clinicians utilize this technology to identify mutations responsible for various ailments, enabling early detection and intervention. Consequently, targeted sequencing has become integral to clinical diagnostics, driving its adoption in healthcare institutions worldwide.

Regional Insights

North America emerged as the dominant region in the global Targeted Sequencing And Resequencing market in 2023, holding the largest market share in terms of value. North America, particularly the United States and Canada, boasts a robust ecosystem of biotechnology companies, research institutions, and academic centers focused on genomics. These entities have invested heavily in cutting-edge technologies for targeted sequencing and resequencing, driving innovation and market growth. With ample funding and resources, North American companies and research organizations lead the way in developing advanced sequencing platforms, bioinformatics tools, and applications for genomic analysis.

Recent Development

• In May 2024, Baylor Genetics, a leading clinical diagnostic laboratory specializing in genetic testing, announced the launch of a new RNA sequencing test, RNAseq, for Whole Exome and Whole Genome Sequencing (WES/WGS). Concurrently, the company has expedited its standard turnaround time for WES and WGS to three weeks, while maintaining its capability to deliver rapid testing with written reports within as little as five days.
• In March 2024, the World Health Organization (WHO) released new recommendations on the utilization of targeted next-generation sequencing (NGS) tests for diagnosing drug-resistant tuberculosis (TB). These recommendations are detailed in the third edition of the Consolidated Guidelines on Tuberculosis, Module 3Diagnosis. Rapid Diagnostics for Tuberculosis Detection. This innovative approach leverages advanced technologies to rapidly identify drug resistance to new anti-TB medications.
• In March 2024, Jammu & Kashmir inaugurated its first 'Next Generation Sequencing' (NGS) laboratories, now operational at two leading hospitals in the Jammu regionthe Government Medical College and Hospital (GMC&H) in Jammu and Gandhi Nagar Hospital. Cutting-edge NGS machines have been installed at both GMC&H Jammu and Gandhi Nagar Hospital. The laboratories have initially begun testing for breast cancer, marking a significant advancement in cancer diagnostics for the region.
• In February 2024, Wasatch Biolabs (WBL), a subsidiary of Renew Biotechnologies and an accredited Oxford Nanopore Technologies laboratory, unveiled its proprietary Targeted DNA Methylation Sequencing Service for researchers and clinical service providers. This innovative technique eliminates the need for amplification and bisulfite conversion, overcoming the common limitations of traditional targeted methylation analysis. WBL's service offers the creation of custom methylation panels targeting an unparalleled range of hundreds to thousands of genomic loci, with enrichment levels between 400x and 2300x.

Key Market Players

• AgilentTechnologies Inc.
• Illumina, Inc.
• F. Hoffmann-La Roche Ltd
• Thermo Fisher Scientific,Inc.
• DNASTAR Inc.
• Bio-Rad Laboratories, Inc.
• Integrated DNATechnologies, Inc.
• Perkin Elmer, Inc.
• RainDance Technologies,Inc.
• Genomatix GmbH
• Macrogen, Inc.
• GATC Biotech Ag