Erythropoietin Stimulating Agents Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented by Type (Epoetin Alfa, Epoetin Beta, Darbepoetin Alfa, And Other Types), Application (Cancer, Renal Disorders, Anti-retroviral Treatment, Neural Diseases, and Other Applications), and By Region, Competition Forecast
Published Date: November - 2024 | Publisher: MIR | No of Pages: 320 | Industry: Healthcare | Format: Report available in PDF / Excel Format
View Details Buy Now 2890 Download Sample Ask for Discount Request CustomizationErythropoietin Stimulating Agents Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented by Type (Epoetin Alfa, Epoetin Beta, Darbepoetin Alfa, And Other Types), Application (Cancer, Renal Disorders, Anti-retroviral Treatment, Neural Diseases, and Other Applications), and By Region, Competition Forecast
| Forecast Period | 2024-2028 |
| Market Size (2022) | 7.45 billion |
| CAGR (2023-2028) | 8.14% |
| Fastest Growing Segment | Asia-Pacific |
| Largest Market | North America |
Market Overview
Global Erythropoietin Stimulating Agents Market has valued at USD 7.45 billion in 2022 and is anticipated to witness an impressive growth in the forecast period with a CAGR of 8.14% through 2028.
Advances in cancer diagnosis and treatment have led to more cancer patients receiving chemotherapy and radiation therapy. These treatments can induce anemia, creating a greater need for ESA drugs.
Key Market Drivers
Advancements in Oncology
Chemotherapy-induced anemia is a common side effect of cancer treatment, leading to fatigue and reduced quality of life. ESAs like Epoetin Alfa and Darbepoetin Alfa have been used to manage CIA. Advancements in oncology have led to the development of more effective and targeted chemotherapy regimens, which may reduce the severity of anemia associated with treatment. Historically, ESAs have been associated with safety concerns, particularly an increased risk of cardiovascular events in cancer patients. Advances in oncology research have contributed to a better understanding of the safety profiles of ESAs and the identification of patient subgroups that may benefit from ESA therapy while minimizing risks. Advances in oncogenomics and personalized medicine have led to more individualized cancer treatment plans. This can include tailoring ESA therapy based on a patient's genetic profile and underlying cancer type, optimizing treatment outcomes while minimizing risks.
Oncology treatment guidelines from organizations like the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO) provide recommendations on the use of ESAs in cancer patients. These guidelines are updated regularly to reflect the latest research findings and advancements in cancer care. Targeted therapies, including monoclonal antibodies and tyrosine kinase inhibitors, have become increasingly important in oncology. These therapies are designed to specifically target cancer cells while sparing healthy ones. As a result, some targeted therapies may have a reduced impact on red blood cell production and anemia, potentially reducing the need for ESAs in certain cases. Oncologists may explore combinations of treatments to improve cancer outcomes. The use of ESAs in conjunction with other supportive care measures, such as blood transfusions or iron supplementation, can be tailored to the specific needs of cancer patients. Ongoing clinical trials in oncology often include investigations into the use of ESAs in combination with new cancer therapies. These trials aim to identify optimal treatment strategies and improve patient outcomes. The development and approval of biosimilar versions of ESAs have launched more cost-effective alternatives to the market. Biosimilars may play a role in reducing the economic burden of ESA therapy in oncology. Advancements in oncology have led to improved strategies for monitoring patients receiving ESA therapy, including regular assessment of hemoglobin levels and cardiovascular risk factors. This allows for early intervention and risk mitigation. This factor will help in the development of
Growth in Aging Population
Anemia is more common in older adults due to various factors, including chronic diseases, nutritional deficiencies, and reduced bone marrow function. As people age, their risk of developing anemia or experiencing a worsening of pre-existing anemia increases. Older adults are more likely to have chronic health conditions such as chronic kidney disease, cancer, and inflammatory disorders. Many of these conditions can lead to anemia. ESAs are commonly used to manage anemia associated with these chronic diseases in older patients. Aging can lead to a decline in the body's natural production of erythropoietin, the hormone that stimulates the production of red blood cells in the bone marrow. This can result in a decreased ability to respond to anemia effectively, making ESAs a valuable treatment option. Anemia can cause symptoms such as fatigue, weakness, and shortness of breath, negatively impacting the quality of life in older adults. ESAs can help alleviate these symptoms and improve overall well-being, making them a desirable treatment option for elderly patients.
In older adults, reducing the need for blood transfusions is often a goal of treatment. ESAs can be used to raise hemoglobin levels, reducing transfusion dependence and associated risks in elderly patients. Medical guidelines often recommend the use of ESAs for managing anemia in older adults, particularly when anemia is related to specific chronic conditions. Healthcare providers may follow these guidelines when treating elderly patients. As populations age, there is an increased focus on improving the overall health and well-being of older adults. Managing anemia is part of supportive care for the aging population, aligning with efforts to enhance their quality of life. In many developed countries, older adults have access to healthcare systems that can provide them with ESA treatments. This accessibility contributes to the demand for ESA therapy among the aging population. As healthcare expenditure increases with aging populations, resources are allocated to addressing the healthcare needs of older adults, including the management of anemia with ESAs. This factor will pace up the demand of
Increasing Prevalence of Anemia-Related Conditions
Anemia is a condition characterized by a deficiency of red blood cells or hemoglobin, which can lead to symptoms such as fatigue, weakness, and reduced oxygen-carrying capacity in the blood.
Anemia is a common complication in individuals living with HIV/AIDS. As the global population living with HIV/AIDS continues to grow, the demand for ESA therapy to address HIV-related anemia remains substantial. Certain nutritional deficiencies, such as iron, vitamin B12, and folate deficiencies, can lead to anemia. Although nutritional deficiencies can be addressed with supplementation and dietary changes, some individuals may still require ESAs, especially if the deficiency is severe or persistent. Patients on hemodialysis for end-stage renal disease often experience anemia due to the loss of erythropoietin-producing capacity in the kidneys. The prevalence of hemodialysis-dependent patients contributes to the demand for ESA therapy. Advances in medical diagnostics and increased awareness of anemia-related conditions have led to more accurate and early diagnosis of anemia. This, in turn, drives the demand for appropriate treatments, including ESAs. Clinical practice guidelines issued by medical associations often recommend the use of ESAs for managing anemia in specific patient populations. These guidelines influence treatment decisions and contribute to the demand for ESAs. This factor will accelerate the demand of
Key Market Challenges
Patent Expirations
When the patents for ESA drugs expire, it allows other pharmaceutical companies to develop and market generic or biosimilar versions of these drugs. This increased competition can lead to a reduction in the price of ESAs as generic or biosimilar products are typically priced lower than the original branded versions. The expiration of patents can result in the erosion of market share for the original ESA manufacturers. Generic and biosimilar versions can capture a significant portion of the market, particularly if they are more competitively priced. The entry of generic and biosimilar competitors often leads to price erosion in the ESA market. Lower prices can impact the revenue and profitability of the original ESA manufacturers. ESA drugs have historically been high-revenue products for pharmaceutical companies, and their patent expirations can lead to a decline in sales revenue for these companies. The ESA market can become fragmented with multiple generic and biosimilar competitors offering similar products. This fragmentation can lead to pricing pressures and increased competition. The competitive pressure resulting from patent expirations may reduce the incentive for original manufacturers to invest in further research and development for ESA products, potentially slowing down innovation in the field.
Changing Treatment Paradigms
As medical knowledge advances, new treatment modalities may emerge that reduce the reliance on ESAs. For example, advances in the management of chronic kidney disease (CKD) or cancer-related anemia might involve alternative approaches such as improved nutrition, iron supplementation, or targeted therapies that address the underlying causes of anemia. Evolving treatment paradigms may lead to a reevaluation of the risk-benefit profile of ESAs. For instance, concerns about ESA safety, such as an increased risk of cardiovascular events, have led to changes in guidelines and recommendations. Healthcare providers may become more cautious in prescribing ESAs in certain situations. Personalized medicine and genetics research can lead to the development of treatment plans tailored to individual patients. In some cases, this may result in a reduced need for ESAs if anemia can be managed through other means or if alternative treatments are more effective for specific patient profiles. Evolving treatment paradigms may emphasize multimodal or combination therapies. In some cases, ESAs may still play a role, but they may be used in conjunction with other treatments, such as iron supplementation or erythropoiesis-stimulating agents with different mechanisms of action. Changes in treatment paradigms often consider cost-effectiveness considerations. Healthcare systems may opt for treatment strategies that are more cost-effective, which could affect the utilization of ESAs. Clinical practice guidelines issued by medical associations may evolve to reflect changes in treatment paradigms and the availability of new treatment options. These guidelines influence treatment decisions and can impact ESA utilization.
Key Market Trends
Shift Toward Epoetin Biosimilars
Biosimilars are biologic drugs that are highly like an already approved reference biologic (in this case, Epoetin) with no clinically meaningful differences in terms of safety and efficacy. The development and approval of biosimilars have been significant in the ESA market. Epoetin biosimilars are often priced lower than the original branded Epoetin products. This cost advantage makes them an attractive option for healthcare systems and providers looking to contain healthcare expenditures while maintaining the quality of care. The introduction of biosimilar versions of Epoetin has increased competition in the ESA market. This competition can lead to reduced prices and increased accessibility of ESA therapies for patients. The availability of Epoetin biosimilars has the potential to expand access to ESA therapy, particularly in regions or healthcare systems where cost considerations may have limited access to the original branded products. The adoption of Epoetin biosimilars can result in substantial healthcare cost savings for both patients and healthcare providers, which is particularly important in regions with budget constraints. Regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have approved Epoetin biosimilars based on rigorous comparability assessments. This regulatory approval has increased confidence in their safety and efficacy.
Segmental Insights
Type Insights
In 2022, the Global Erythropoietin Stimulating Agents Market largest share was held by Epoetin Alfa segment in the forecast period and is predicted to continue expanding over the coming years.
Application Insights
In 2022, the Global Erythropoietin Stimulating Agents Market was dominated by Cancer Application segment in the forecast period and is predicted to continue expanding over the coming years.
Regional Insights
The North America region dominates the Global Erythropoietin Stimulating Agents Market in 2022. North America, particularly the United States and Canada, boasts a well-developed healthcare infrastructure with advanced medical facilities, a high standard of care, and easy access to healthcare services. This infrastructure facilitates the prescription, administration, and monitoring of ESA therapies.
Recent Developments
- In July 2020, A phase III trial is being conducted to see if efepoetinalfa delivered subcutaneously is as efficient and well tolerated assubcutaneous Mircera for the treatment and maintenance of anaemia in CKDpatients not receiving dialysis. An 8-week evaluation phase will be used to gauge the effectiveness ofthe corrective treatment after a 20-week correction period for dosage titrationand Hb correction. To determine long-term safety and maintenance effect,subjects who respond to efepoetin alfa (defined as an increase in Hb 1.0 g/dLversus baseline and Hb level within 10 - 12 g/dL range without bloodtransfusion during the 28 weeks after the first dose) will be randomly assignedto receive subcutaneous efepoetin alfa once every 2W or once every 4W for anadditional 24-week extension period.
- In February 2020, A Phase III clinical research on the effectiveness ofintravenous iron injection, Ferinject, in cancer patients with anaemia wasstarted at Samsung Medical Centre as part of a multicenter randomisedinvestigation.
Key Market Players
- Amgen Inc.
- BioconLimited
- CelltrionInc.
- F.Hoffmann-La Roche Ltd
- Intas PharmaceuticalsLtd
- Johnsonand Johnson
- PfizerInc.
- TevaPharmaceutical Industries Ltd
- ThermoFisher Scientific
- LGLifesciences, Ltd
- NovartisAG(Sandoz)
- PanaceaBiotec Ltd
| By Type | By Application | By Region | By Region |
| Epoetin Alfa Epoetin Beta Darbepoetin Alfa Other Types | Cancer Renal Disorders Anti-retroviral Treatment Neural Diseases Other Applications | North America Asia-Pacific Europe South America Middle East & Africa | Saudi Arabia UAE Qatar Kuwait Bahrain Rest of Middle East |
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