Cancer Biologics Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By Product (Monoclonal Antibodies, Cytokine-Based Immunotherapy, Cancer Vaccines, CAR-T Cell Therapy, Immune Checkpoint Inhibitors), By Application (Non-small Cell Lung Cancer, Prostate Cancer, Breast Cancer, Acute Myeloid Leukemia, Lymphoma, Others), by End User (Hospitals & Clinics, Ambu
Published Date: November - 2024 | Publisher: MIR | No of Pages: 320 | Industry: Healthcare | Format: Report available in PDF / Excel Format
View Details Buy Now 2890 Download Sample Ask for Discount Request CustomizationCancer Biologics Market – Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By Product (Monoclonal Antibodies, Cytokine-Based Immunotherapy, Cancer Vaccines, CAR-T Cell Therapy, Immune Checkpoint Inhibitors), By Application (Non-small Cell Lung Cancer, Prostate Cancer, Breast Cancer, Acute Myeloid Leukemia, Lymphoma, Others), by End User (Hospitals & Clinics, Ambu
| Forecast Period | 2024-2028 |
| Market Size (2022) | 94.10 billion |
| CAGR (2023-2028) | 7.17% |
| Fastest Growing Segment | Immune Checkpoint Inhibitors Segment |
| Largest Market | North America |
Market Overview
Global Cancer Biologics Market has valued at USD 94.10 billion in 2022 and is anticipated to witness an impressive growth in the forecast period with a CAGR of 7.17% through 2028.
Ongoing research and innovation in the field of biotechnology and immunology have led to the development of more effective and targeted cancer biologics. New discoveries and technological advancements continue to drive the market forward.
Key Market Drivers
Advancements in Biologics Development
Immune checkpoint inhibitors, such as anti-PD-1 and anti-PD-L1 antibodies, have revolutionized cancer treatment. They block inhibitory signals that prevent the immune system from recognizing and attacking cancer cells. Immunotherapies have demonstrated remarkable success in various cancer types, including melanoma, lung cancer, and more. Chimeric Antigen Receptor T-cell (CAR-T) therapy is a groundbreaking approach where a patient's own T cells are genetically modified to express a receptor that targets cancer cells. CAR-T therapies have shown remarkable results in certain blood cancers, such as leukemia and lymphoma. Bispecific antibodies can target two different antigens simultaneously, often on both cancer cells and immune cells. These innovative antibodies enhance the immune system's ability to recognize and attack cancer cells, leading to improved treatment outcomes. Advancements in genomics and biomarker research have enabled the development of biologics tailored to specific genetic mutations and protein markers present in cancer. This personalized approach improves treatment efficacy and reduces side effects. The development of biosimilars, which are highly similar but more affordable versions of established biologics, has increased access to cancer treatments, potentially lowering healthcare costs. Monoclonal antibodies continue to be at the forefront of cancer biologics development. New monoclonal antibodies are constantly being researched and developed to target specific cancer markers and pathways.
Cancer vaccines, such as the human papillomavirus (HPV) vaccine and therapeutic cancer vaccines, have been developed to prevent certain types of cancer and boost the body's immune response against existing cancer cells. Targeted biologics have been designed to interfere with specific pathways that drive cancer growth. These therapies aim to disrupt the molecular signals that allow cancer cells to proliferate while sparing healthy cells. Researchers are investigating the synergistic effects of combining different biologics, such as combining immunotherapies with targeted therapies or chemotherapy. These combinations aim to enhance the overall therapeutic impact and reduce the likelihood of resistance. Advancements in gene editing technologies, such as CRISPR-Cas9, offer the potential to modify cancer cells or enhance the body's immune response to cancer. The use of nanoparticles for drug delivery and targeting specific cancer cells has gained attention. Nanotechnology can improve drug delivery efficiency and reduce side effects. Biologics production has become more efficient and scalable, ensuring consistent product quality and supply. Advanced manufacturing techniques have reduced production costs. The development of companion diagnostic tests helps identify the most suitable patients for specific biologic therapies, ensuring a more targeted and effective approach to treatment. This factor will help in the development of the
Rising Investment in Oncology
Higher investment in oncology research and development (R&D) has led to the discovery and development of new cancer biologics. Pharmaceutical and biotechnology companies allocate substantial funds to conduct clinical trials, explore innovative treatment modalities, and discover novel targets for biologic therapies. Increased funding has led to the discovery of new cancer targets and the development of biologics specifically designed to target these markers. This has expanded the range of found at treatment options and personalized medicine approaches. Investment supports a growing number of clinical trials, including large-scale, multi-phase trials for cancer biologics. These trials are essential for evaluating the safety and efficacy of new treatments, ultimately leading to regulatory approvals. Investment has fueled the growth of biotechnology startups dedicated to oncology. These startups often focus on niche areas and novel biologic therapies, contributing to the diversity of treatment options.
Greater investment encourages innovation in biologics development. Researchers and companies explore novel therapeutic approaches, such as bispecific antibodies, gene editing technologies, and advanced immunotherapies. Investment in oncology research and development extends beyond well-established markets, offering cancer patients worldwide access to cutting-edge biologic treatments. Investment enables the exploration of combination therapies, where biologics are used in conjunction with other treatment modalities, such as chemotherapy, targeted therapies, or radiation therapy. These combinations have shown promise in enhancing treatment efficacy. Funding supports advancements in biologics manufacturing processes, making production more efficient, cost-effective, and scalable. This ensures a stable supply of these treatments. Ongoing investment in oncology leads to the exploration of biologics in new clinical indications and cancer types, broadening the market and increasing treatment options for patients. Funds are allocated to navigate the complex regulatory pathways associated with biologics, increasing the number of approved treatments found at for patients. Investment in biomarker research and diagnostic tools enables a more targeted and personalized approach to cancer treatment. Biologics are often used in conjunction with companion diagnostics to identify the most appropriate therapy for individual patients. This factor will pace up the demand of the
Increasing Awareness and Patient Advocacy
Patient advocacy groups and awareness campaigns provide valuable information about cancer biologics, their benefits, and their availability. This empowers patients and their families to make informed decisions about their treatment options. Increased awareness often leads to earlier cancer detection, which can result in a better prognosis and more treatment options, including biologics. Patients and their advocates often push for access to the latest and most advanced cancer treatments, including biologics. This demand can lead to changes in healthcare policies and increased funding for these therapies. Patients who are aware of clinical trials involving cancer biologics may be more willing to participate in research, helping to advance the development of new treatments and expand treatment options. Patient advocacy and awareness efforts have contributed to the push for personalized medicine. Patients and advocacy groups advocate for treatments tailored to individual genetics and biomarkers, which is a central feature of many biologic therapies. Increased awareness can lead to greater patient access to specialized clinics and healthcare providers experienced in administering cancer biologics.
Advocacy groups often raise funds for cancer research, including biologics development, through events, donations, and partnerships. This financial support helps drive further research and innovation. Increased awareness efforts aim to reduce the stigma surrounding cancer and cancer treatments, making it more acceptable for patients to explore various treatment options, including biologics. Advocacy groups often advocate for policy changes and regulatory reforms to improve the approval and accessibility of biologics, which can directly impact demand. Greater awareness can lead to higher enrollment in clinical trials, helping researchers gather valuable data on the efficacy and safety of biologic treatments, ultimately driving demand if positive results are achieved. By promoting early detection, personalized treatment, and advanced therapies like biologics, patient advocacy and awareness efforts contribute to improved patient outcomes, creating a growing demand for these treatments. Patient advocacy may focus on improving the quality of life for cancer patients. Biologics often have a more favorable side effect profile compared to traditional chemotherapy, making them a preferred choice for patients seeking a better quality of life during treatment. This factor will accelerate the demand of the Global Cancer Biologics Market.
Key Market Challenges
High Development Costs
Developing biologic therapies is a highly complex and resource-intensive process. It involves extensive preclinical research, clinical trials, and regulatory requirements, which all require substantial financial investments. Conducting clinical trials for cancer biologics, including Phase I, II, and III trials, is a costly endeavor. These trials involve patient recruitment, monitoring, data collection, and compliance with regulatory standards. Regulatory authorities, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have stringent requirements for the approval of biologics. Meeting these standards necessitates significant investment in research and documentation. Biologics are challenging to manufacture due to their complexity. Establishing and maintaining the infrastructure for the large-scale production of biologics requires substantial capital. Maintaining the quality and consistency of biologics is vital to ensuring safety and efficacy. Stringent quality control and assurance processes contribute to development costs. Identifying appropriate biomarkers and targets for cancer biologics can be a resource-intensive process, requiring specialized research and expertise. Patient recruitment and ongoing monitoring in clinical trials involve substantial costs, including patient compensation, site expenses, and data management.
Resistance and Response Variability
Some cancer patients may exhibit innate or acquired resistance to certain biologics, meaning that the treatment may not be as effective as initially hoped. Tumors are often heterogeneous, with different regions of the tumor having distinct genetic profiles and responses to treatment. This heterogeneity can lead to resistance in certain tumor subpopulations. Patients can respond differently to biologic therapies due to factors such as genetics, overall health, and the presence of other medical conditions. This response variability can make it challenging to predict treatment outcomes accurately. The presence or absence of specific biomarkers, which are often used to select patients for certain biologics, can vary between individuals. This variability can impact the treatment's effectiveness.
Key Market Trends
Advancements in Monoclonal Antibodies
Monoclonal antibodies have been a cornerstone of cancer treatment for years, and ongoing advancements in this field are expanding their potential and impact. Bispecific monoclonal antibodies are designed to simultaneously target two different antigens or receptors, often present on cancer cells and immune cells. These bi-specific antibodies can enhance the immune system's ability to recognize and attack cancer cells, potentially leading to improved treatment outcomes. Immune checkpoint inhibitors are monoclonal antibodies that block proteins like PD-1 and PD-L1 to unleash the immune system's ability to attack cancer cells. Ongoing research is expanding the use of these inhibitors in various cancer types and as combination therapies. ADCs (Antibody-Drug Conjugates) are monoclonal antibodies that are chemically linked to cytotoxic drugs. These smart bombs selectively target cancer cells, delivering the drug payload directly to the tumor while sparing healthy tissue. Advancements in ADC technology have led to more effective and less toxic treatments. Researchers are continually identifying new cancer targets for monoclonal antibodies. This involves a deeper understanding of the molecular and genetic basis of cancer, leading to more precise targeting. Monoclonal antibodies are often used in combination with other immunotherapies or targeted therapies, leading to the development of innovative combination treatments to enhance treatment efficacy. Some monoclonal antibodies are being developed for subcutaneous administration, making treatment more convenient for patients compared to intravenous infusions. Advances in antibody engineering have led to the development of next-generation antibodies with enhanced properties, such as increased binding affinity, longer half-life, and improved tumor penetration. The identification of predictive biomarkers helps select patients who are most likely to respond to specific monoclonal antibody therapies, enabling a more personalized approach to treatment.
Segmental Insights
Product Insights
In 2022, the Global Cancer Biologics Market largest share was held by Immune Checkpoint Inhibitors segment and is predicted to continue expanding over the coming years.
Application Insights
In 2022, the Global Cancer Biologics Market largest share was held by Acute Myeloid Leukemia segment and is predicted to continue expanding over the coming years.
End-User Insights
Hospitals & Clinics
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Regional Insights
The North America region dominates the Global Cancer Biologics Market in 2022. North America, particularly the United States and Canada, boasts highly advanced healthcare infrastructure and medical facilities. This allows for early diagnosis and effective treatment of cancer, including the use of biologics. The region is home to numerous leading biopharmaceutical companies, research institutions, and academic centers that are at the forefront of cancer biologics research and development. The United States has a well-established regulatory framework for the approval of biologics. The U.S. Food and Drug Administration (FDA) has a robust and transparent approval process that has encouraged the development and adoption of biologics. North America often serves as an early launch market for new biologics. This, in turn, leads to higher adoption rates and greater market share. Many global clinical trials for cancer biologics are conducted in North America, as it has a diverse and large patient population, streamlined regulatory processes, and skilled clinical trial infrastructure.
Recent Developments
- In May 2020, The Food andDrug Administration has granted approval for the use of atezolizumab incombination with bevacizumab, marketed as TECENTRIQ and AVASTIN by GenentechInc., in the treatment of patients diagnosed with unresectable or metastatichepatocellular carcinoma. This approval applies to patients who have notundergone prior systemic therapy.
- In January 2020, Roche hassubmitted a supplemental biologics license application (sBLA) to the US Foodand Drug Administration (FDA) for the use of Tecentriq (atezolizumab) incombination with Avastin (bevacizumab) for the treatment of unresectablehepatocellular carcinoma (HCC), a type of liver cancer. This application aimsto gain approval for utilizing the combination in patients who have notpreviously received systemic therapy. Tecentriq is a monoclonalantibody that targets PD-L1, and Avastin is a biologic antibody that acts onthe vascular endothelial growth factor (VEGF) protein. By combining these twodrugs, the goal is to enhance the immune system's efficacy in combating cancer.
Key Market Players
- Roche Holding AG
- Novartis AG
- Merck & Co., Inc.
- Bristol-Myers Squibb Company
- Amgen Inc.
- Johnson & Johnson
- Pfizer Inc.
- AstraZeneca plc
- Eli Lilly and Company
- AbbVie Inc.
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