Organoids and Spheroids Market – By Type (Organoids, Spheroids), Application (Developmental Biology, Personalized Medicine), End-use (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes) – Global Forecast (2024 ­ 2032)

Organoids and Spheroids Market – By Type (Organoids, Spheroids), Application (Developmental Biology, Personalized Medicine), End-use (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes) – Global Forecast (2024 ­ 2032)

Organoids and Spheroids Market Size

Organoids And Spheroids Market was valued at USD 1.1 billion in 2023 growing at a CAGR of 19.1% between 2024 and 2032, driven by factors such as the increase in demand for personalized medicines, a rise in investments toward R&D activities, and a shift in preference toward organoid 3D cell cultures for cancer research.

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Moreover, the surge in technological advancement in 3D spheroids technologies is expected to boost the market growth. For instance, in July 2023, Molecular Devices, LLC., a leading high-performance life science solutions provider, continues industrializing biology with its organoid line expansion services to support next-generation drug discovery. The offering leverages proprietary bioreactor and bioprocess technology to scale up the production of standardized, assay-ready organoids originating from customer-supplied organoid lines or patient-derived xenografts (PDX).

Organoids are complex, self-organizing structures derived from stem cells or tissue-specific progenitor cells. Organoids can be generated from various cells and including pluripotent stem cells or adult tissue-specific stem cells and can recapitulate the cellular diversity and spatial organization found in native tissues. Spheroids are simple aggregates of cells that form rounded, 3D structures in culture. Unlike organoids, which aim to replicate the structural and functional complexity of specific tissues or organs, spheroids are often composed of one or more cell types and lack the tissue-specific organization seen in organoids.
 

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Organoids and Spheroids Market Trends

• Technological advancements in 3D spheroid culture are instrumental in propelling the growth of the market. Cutting-edge techniques such as microfluidics and bioprinting enable precise control over the spatial organization of cells within spheroids, resulting in more complex and physiologically relevant structures.
• In addition, advanced imaging technologies allow high-resolution visualization and analysis of spheroid morphology and dynamics, facilitating high-content screening for drug discovery and toxicity testing.
• Moreover, integration of multi-omics approaches with 3D spheroid cultures provides comprehensive insights into cellular phenotypes and drug responses. For instance, in June 2021 Corning Incorporated announced the launch of HepGo Assay-ready 3D liver spheroid kit, the first plug-and-play solution to include 96 pre-plated primary human hepatocyte (PHH) spheroids in a single-spheroid microplate (one uniform spheroid per well) and HepGo Hepatocyte companion cell culture media. The kit provides a convenient way for customers to use 3D PHH liver spheroids for various applications, including hepatotoxicity assays. This streamlines the process by minimizing manual steps and reducing potential errors, that boosts the growth of the market.

Organoids and spheroids Market Analysis

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Based on the type, the global market is classified into organoids and spheroids. The organoids segment dominated the market with revenue of USD 796.9 million in 2023.

• The rise in the adoption of organoids in various applications such as disease modeling, pathogenesis, drug screening, and regenerative medicine is the major factor that propels the growth of the market.
• Moreover, the advancement in stem cell technology particularly in pluripotent stem cells (iPSCs) and adult stem cells, has facilitated the generation of organoids from various tissues and organs that boost the growth of the market.
• In addition, the ongoing advancements in biotechnology, microfabrication, and imaging technologies have improved the reproducibility, scalability, and functionality of organoid cultures. Innovations such as microfluidics, bioprinting, and high-content imaging enable the generation and characterization of complex organoid models with higher throughput and resolution, driving their adoption in academic research and industrial applications

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Based on the application, the global organoids and spheroids market is classified into developmental biology, personalized medicine, regenerative medicine, disease pathology studies, and drug toxicity & efficacy testing. The developmental biology segment dominated the market with market share of 32.1% in 2023.

• The rising usage of organoid and spheroid culture systems for developmental biology and ongoing advancement in microfluidics and bioprinting are the major factors that boost the growth of the market during the forecast period.
• Moreover, organoid biology presents a great opportunity to evaluate the fundamentals of human developmental biology that have been obtained through classical approaches. In addition, organoids and spheroids provide unique platforms for studying developmental processes in vitro. These models offer insights into the molecular mechanisms underlying embryonic development and tissue patterning, advancing the understanding of developmental biology thus driving the market growth.

Based on end-use, the organoids and spheroids market are classified into pharmaceutical and biotechnology companies, academic & research institutes, and hospitals & diagnostic centers. Pharmaceutical and biotechnology companies’ segment is expected to exhibit 19.4% CAGR between 2024 - 2032

• Pharmaceutical and biotechnology companies are increasingly investing in stem cell research to develop innovative healthcare solutions. Organoids and spheroids play a crucial role in tissue engineering, regenerative medicine, and personalized medicine, addressing unmet medical needs.
• Moreover, organoids and spheroids offer more physiologically relevant models for drug screening and toxicity testing compared to traditional 2D cell cultures. The ability to mimic tissue architecture, cell-cell interactions, and physiological functions enhances the predictivity of preclinical studies, reducing the risk of late-stage drug failures and improving overall success rates in drug development pipelines

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In 2023, North America secured a substantial market share of 42.7% in the global organoids and spheroids market and is expected to dominate throughout the forecast period.

• Technology advancement have made it possible to create 3D organoids and spheroids are responsible for the increase in the use of organoid-based research models in the biotechnology industry in U.S. and Canada.
• With their greater accuracy in representing human tissue architecture, these novel models have shown to be more successful than conventional 2D cell culture platforms, that increases the demand for 3D cell culture spheroids, thus driving the growth of the market.
• Moreover, researchers can get more accurate and predicted results from their studies by establishing a microenvironment that closely resembles in vivo circumstances.

The organoids and spheroids market in U.S. is expected to exhibit 19.3% CAGR between 2024 - 2032.

• The rise in the demand for personalized medicine coupled with rapid increase in the prevalence of chronic disease in U.S. is expected to drive the growth of the market.
• Moreover, the presence of local key players such as Corning Incorporated, Perkin Elmer, Thermo Fisher Scientific is expected to enhance the growth of market.

Germany to experience the highest growth rate in the market, outstripping other countries in Europe in the assessment period.

• The upsurge in technological advancement has played a major role in driving the growth of the market. In addition, the presence of key market players involved in R&D activities in stem cell technology particularly induced pluripotent stem cells (iPSCs) and adult stem cells, has facilitated the generation of organoids from various tissues and organs is one of the major factors that propel the growth of the market.

The India organoids and spheroids market is expected to grow with a significant CAGR during the forecast period.

• The rise in the prevalence of chronic disease and increase in the number of collaborations and partnership among key market entities are the major factors that increase the R&D activities for stem cells, thus boosts the market growth.

Brazil secured a substantial market share in the global market.

• As Brazil's economy grows, there is an increasing allocation of funds towards healthcare, including research and development. This allows for more investment in advanced technologies like organoids and spheroids, which hold promise for drug discovery, personalized medicine, and disease modeling.
• Moreover, advances in tissue engineering, 3D cell culture techniques, and biomaterials have improved the scalability, reproducibility, and functionality of organoids and spheroids. These technological advancements make them more attractive for applications in drug screening, toxicology testing, and regenerative medicine, driving market growth.

Organoids and Spheroids Market Share

The competitive landscape of the market is characterized by the presence of established pharmaceutical and biotechnology companies that involved in stem cell research, drug discovery and development and tissue engineering & regenerative medicine vying for market share. Key players are engaging in strategic initiatives such as collaboration, investment, and partnerships to strengthen their product portfolio. The companies are actively adopting a multi-pronged approaches to address the rising demand for organoids and spheroids.

Organoids and Spheroids Market Companies

Prominent players operating in the organoids and spheroids industry are as mentioned below

• STEMCELL Technologies Inc.
• Corning Incorporated
• Merck KGaA
• Greiner Bio-One
• InSphero Inc.
• Promega Corporation
• Thermo Fisher Scientific Inc.
• Lonza Group Ltd.
• Prellis Biologics
• AMSBIO LLC

Organoids and Spheroids Industry News

• In March 2023, MIMETAS, a leading company in the field of organ-on-a-chip-based disease models, announces that it has launched its Adult Stem Cell (ASC)-derived tubular organoids in an assay-ready format. As part of its OrganoReady product line, MIMETAS offers two organoid-based productsASC-derived Colon1 and Kidney2 Organoid tubules.
• In March 2021, Bio-Techne released its new Cultrex UltiMatrix Reduced Growth Factor Basement Membrane Extract (RGF BME) to support organoid and pluripotent stem cell cultures. Cultrex UltiMatrix RGF BME is an extracellular-matrix hydrogel to be used during the culturing of organoids and pluripotent stem cells. The product addresses the need for a dependable, high-concentration cell-scaffolding matrix with compositional and physical properties specifically designed for use in generating 2D and 3D cell culture models.

The organoids and spheroids market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2021 - 2032 for the following segments

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Market, By Type

• Organoids
  • By Type
    • Neural organoids
    • Hepatic organoids
    • Intestinal organoids
    • Other organoid types
  • By Method
    • General submerged method for organoid culture
    • Crypt organoid culture techniques
    • Air Liquid Interface (ALI) method
    • Other organoid methods
  • By Source
    • Primary tissue
    • Stem cells
• Spheroids
  • By Type
    • Multicellular tumor spheroids
    • Neurospheres
    • Mammospheres
    • Hepatospheres
  • By Method
    • Micropatterned plates
    • Low cell attachment plates
    • Hanging drop method
    • Other spheroid methods
  • By Source
    • Cell line
    • iPSCs derived cells

Market, By Application

• Developmental biology
• Personalized medicine
• Regenerative medicine
• Disease pathology studies
• Drug toxicity & efficacy testing

Market, By End-use

• Pharmaceutical & biotechnology companies
• Academic & research institutes
• Hospital & diagnostic centers

The above information is provided for the following regions and countries

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Netherlands
  • Rest of Europe
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East and Africa
  • South Africa
  • Saudia Arabia
  • UAE
  • Rest of Middle East and Africa